Norcantharidin inhibits growth of human HepG2 cell-transplanted tumor in nude mice and prolongs host survival

In this study, norcantharidin was compared with adriamycin and mitomycin C for its inhibitory action in the growth of cultured human hepatocellular carcinoma HepG2 cells. The IC 50 of adriamycin and mitomycin C on HepG2 cells was 7.3 μM and 27 μM, respectively, whereas the IC 50 of norcantharidin fo...

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Bibliographic Details
Published in:Cancer letters 1997-07, Vol.117 (1), p.93-98
Main Authors: Yang, Er-Bin, Tang, Wen-Ying, Zhang, Kai, Cheng, Li-Yao, Mack, Peter O.P
Format: Article
Language:English
Subjects:
Adriamycin
Animals
Antineoplastic agents
Antineoplastic Agents - pharmacology
Biological and medical sciences
Body Weight - drug effects
Bridged Bicyclo Compounds, Heterocyclic - pharmacology
Carcinoma, Hepatocellular - pathology
Chemotherapy
Doxorubicin - pharmacology
Hepatocellular carcinoma
Humans
Liver cancer
Liver Neoplasms - pathology
Medical sciences
Mice
Mice, Nude
Mitomycin - pharmacology
Mitomycin C
Mylabris
Neoplasm Transplantation
Norcantharidin
Pharmacology. Drug treatments
Survival Analysis
Tumor Cells, Cultured
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Summary:In this study, norcantharidin was compared with adriamycin and mitomycin C for its inhibitory action in the growth of cultured human hepatocellular carcinoma HepG2 cells. The IC 50 of adriamycin and mitomycin C on HepG2 cells was 7.3 μM and 27 μM, respectively, whereas the IC 50 of norcantharidin for inhibiting the growth of HepG2 cells was as high as 1900 μM. After HepG2 tumor-bearing nude mice were treated with 12 daily intraperitoneal injections of norcantharidin (2 mg/kg), the increase in tumor size was significantly slower than that of untreated controls. The mean survival time of untreated tumor-bearing nude mice was 129 days, whereas in the tumor-bearing nude mice treated with norcantharidin, the mean survival time was significantly prolonged to 194 days ( P
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(97)00206-1