Carbohydrate supplementation affects blood granulocyte and monocyte trafficking but not function after 2.5 h or running

This randomized, double-blind, placebo-controlled study was designed to determine the influence of carbohydrate supplementation on the granulocyte and monocyte response to 2.5 h of high-intensity running [76.7 +/- 0.4% of maximal oxygen consumption (VO2max)]. Thirty experienced marathon runners (VO2...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of clinical nutrition 1997-07, Vol.66 (1), p.153-159
Main Authors: Nieman, DC, Fagoaga, OR, Butterworth, DE, Warren, BJ, Utter, A, Davis, JM, Henson, DA, Nehlsen-Cannarella, SL
Format: Article
Language:English
Subjects:
Adult
Beverages
Biological and medical sciences
Blood Glucose - drug effects
Carbohydrate Metabolism
Carbohydrates
Carbohydrates - pharmacology
Diet
Double-Blind Method
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Granulocytes - drug effects
Granulocytes - immunology
Humans
Hydrocortisone - blood
Immune System - drug effects
Immunobiology
Male
Medical research
Middle Aged
Modulation of the immune response (stimulation, suppression)
Monocytes - drug effects
Monocytes - immunology
Oxygen Consumption - drug effects
Phagocytosis - drug effects
Running
Running - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This randomized, double-blind, placebo-controlled study was designed to determine the influence of carbohydrate supplementation on the granulocyte and monocyte response to 2.5 h of high-intensity running [76.7 +/- 0.4% of maximal oxygen consumption (VO2max)]. Thirty experienced marathon runners (VO2max 53.4 +/- 1.0 mL.kg-1.min-1, age 41.5 +/- 1.4 y) were randomly assigned to carbohydrate-supplement (n = 17) and placebo (n = 13) groups. Subjects rested for 10-15 min before a blood sample was taken at 0715, and then ingested 0.75 L carbohydrate beverage or placebo. At 0730 subjects began running at 75-80% of VO2max for 2.5 h, and drank 0.25 L carbohydrate or placebo fluid every 15 min. Immediately after the 2.5-h run (1000), another blood sample was taken, followed by 1.5-h, 3-h, and 6-h recovery samples. Carbohydrate supplementation had a significant effect compared with placebo on the pattern of change in plasma glucose and cortisol, and the blood concentration of neutrophils (F[14, 112] = 5.13, P = 0.001) and monocytes (F[14, 112] = 4.78, P = 0.001), but not on blood granulocyte and monocyte phagocytosis or oxidative burst activity after 2.5 h of intensive running.
ISSN:0002-9165
1938-3207
DOI:10.1093/ajcn/66.1.153