Poliovirus Surveillance: Building the Global Polio Laboratory Network

A network of virologic laboratories has been established by the World Health Organization to conduct surveillance for wild poliovirus and to provide evidence for the certification of poliomyelitis eradication. The network consists of >60 national laboratories isolating and identifying polioviruse...

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Bibliographic Details
Published in:The Journal of infectious diseases 1997-02, Vol.175 (Supplement-1), p.S113-S116
Main Authors: Hull, Barbara P., Dowdle, Walter R.
Format: Article
Language:English
Subjects:
Adolescent
Antiserum
Cell culture techniques
Child
Child, Preschool
Countries
Epidemiologic and Virologic Surveillance Issues
Humans
Immunization
Infant
Laboratories - organization & administration
Laboratories - standards
Polio
Poliomyelitis
Poliomyelitis - prevention & control
Poliovirus - isolation & purification
Population Surveillance - methods
Quality Assurance, Health Care
Specimens
Training
Vaccination
Virology
World Health Organization
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Description
Summary:A network of virologic laboratories has been established by the World Health Organization to conduct surveillance for wild poliovirus and to provide evidence for the certification of poliomyelitis eradication. The network consists of >60 national laboratories isolating and identifying polioviruses within countries; 16 regional reference laboratories, providing intratypic differentiation of wild and vaccine strains and assisting with quality assurance and training; and 6 global specialized laboratories, conducting research, preparing reference reagents, and providing genomic sequencing of wild polioviruses, advanced training, and expert virologic advice. Laboratories collaborate with national eradication programs in the detection, reporting, clinical investigation, and virologic testing of stool specimens obtained in connection with cases of acute flaccid paralysis and, where indicated, from healthy children and the environment. A quality assurance system, leading to World Health Organization accreditation, involves training in standardized techniques, use of centrally prepared typing antisera, annual proficiency testing and follow-up action, and monitoring of standard performance indicators.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/175.Supplement_1.S113