Identification of a Chemokine Receptor Encoded by Human Cytomegalovirus as a Cofactor for HIV-1 Entry

The human cytomegalovirus encodes a β-chemokine receptor (US28) that is distantly related to the human chemokine receptors CCR5 and CXCR4, which also serve as cofactors for the entry into cells of human immunodeficiency virus-type 1 (HIV-1). Like CCR5, US28 allowed infection of CD4-positive human ce...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1997-06, Vol.276 (5320), p.1874-1878
Main Authors: Pleskoff, Olivier, Tréboute, Carole, Brelot, Anne, Heveker, Nikolaus, Seman, Michel, Alizon, Marc
Format: Article
Language:English
Subjects:
AIDS-Related Opportunistic Infections - virology
AIDS/HIV
Amino Acid Sequence
Biological and medical sciences
Cell Fusion
Cell lines
Cellular biology
Chemokine receptors
Chemokines
Coculture Techniques
Cytomegalovirus
Cytomegalovirus - genetics
Cytomegalovirus - physiology
Cytomegalovirus Infections - virology
Cytomegaloviruses
Fluorescence
Fundamental and applied biological sciences. Psychology
Giant Cells
HeLa Cells
HIV
HIV 1
HIV infection
HIV infections
HIV Infections - virology
HIV-1 - physiology
HIV-2 - physiology
Human immunodeficiency virus
human immunodeficiency virus 1
Humans
Infections
Medical research
Membrane Proteins - physiology
Microbiology
Molecular Sequence Data
Open reading frames
Physiological aspects
Receptors
Receptors, CCR2
Receptors, CCR5
Receptors, Chemokine
Receptors, CXCR4
Receptors, Cytokine - genetics
Receptors, Cytokine - physiology
Receptors, HIV - genetics
Receptors, HIV - physiology
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Syncytia
Transfection
Tumor Cells, Cultured
Viral Proteins - genetics
Viral Proteins - physiology
Virology
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Description
Summary:The human cytomegalovirus encodes a β-chemokine receptor (US28) that is distantly related to the human chemokine receptors CCR5 and CXCR4, which also serve as cofactors for the entry into cells of human immunodeficiency virus-type 1 (HIV-1). Like CCR5, US28 allowed infection of CD4-positive human cell lines by primary isolates of HIV-1 and HIV-2, as well as fusion of these cell lines with cells expressing the viral envelope proteins. In addition, US28 mediated infection by cell line-adapted HIV-1 for which CXCR4 was an entry cofactor.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.276.5320.1874