Large B-Cell Lymphoma of the Uterine Corpus: Case Report with Immunohistochemical and Molecular Study

Primary lymphoma of the uterine corpus (PLUC) is an extremely rare neoplasm. We report a case of PLUC in a 78-year-old woman with vaginal bleeding without hepatosplenomegaly, adenopathies, or bone marrow infiltration, classified as stage I. A diagnosis of diffuse large B-cell lymphoma was made in en...

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Bibliographic Details
Published in:Gynecologic oncology 1997-06, Vol.65 (3), p.534-538
Main Authors: Alvarez, A., Ortiz, J.A., Sacristán, F.
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
DNA, Neoplasm - analysis
Female
Hematologic and hematopoietic diseases
Humans
Immunohistochemistry
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, B-Cell - pathology
Medical sciences
Uterine Neoplasms - pathology
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Summary:Primary lymphoma of the uterine corpus (PLUC) is an extremely rare neoplasm. We report a case of PLUC in a 78-year-old woman with vaginal bleeding without hepatosplenomegaly, adenopathies, or bone marrow infiltration, classified as stage I. A diagnosis of diffuse large B-cell lymphoma was made in endometrial curettage tissue. Immunohistochemical study showed tumoral cells of B-cell nature. Two different polymerase chain reaction (PCR) techniques showed immunoglobulin heavy chain gene rearrangement and we could not demonstrate, with PCR technique, either Epstein–Barr virus or papilloma virus infection. Total hysterectomy with bilateral salpingo-oophorectomy was carried out and adjuvant chemotherapy was given. She was alive and free of disease after a follow-up period of 7 years, and the patient has been in perfect health.
ISSN:0090-8258
1095-6859
DOI:10.1006/gyno.1997.4679