Initial Experience with SPECT Imaging of the Brain Using I-123 p-Iodoamphetamine in Focal Epilepsy

Nineteen patients with complex partial seizures refractory to medical treatment were examined with routine electroencephalograpy (EEG), video EEG monitoring, computed tomography or magnetic resonance imaging, neuropsychological tests and interictal single photon emission computed tomography (SPECT)...

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Bibliographic Details
Published in:Clinical nuclear medicine 1989-06, Vol.14 (6), p.428-430
Main Authors: LaMANNA, MARGARET M, SUSSMAN, NEIL M, HARNER, RICHARD N, KAPLAN, LINDA R, HERSHEY, BEVERLY L, BERNSTEIN, DEBORAH R, GOLDSTEIN, PERRY, PARKER, JANET A, WOLODZKO, JOHN G, POPKY, GEORGE L
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Amphetamines
Biological and medical sciences
Brain - diagnostic imaging
Brain - pathology
Electroencephalography
Epilepsies, Partial - diagnosis
Epilepsies, Partial - diagnostic imaging
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Iodine Radioisotopes
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
Neuropsychological Tests
Tomography, Emission-Computed
Tomography, X-Ray Computed
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Description
Summary:Nineteen patients with complex partial seizures refractory to medical treatment were examined with routine electroencephalograpy (EEG), video EEG monitoring, computed tomography or magnetic resonance imaging, neuropsychological tests and interictal single photon emission computed tomography (SPECT) with 1-123 iodoamphetamine (INT). In 18 patients, SPECT identified areas of focal reduction in tracer uptake that correlated with the epileptogenic focus identified on the EEG. In addition, SPECT disclosed other areas of neurologic dysfunction as elicited on neuropsychological tests. Thus, IMP SPECT is a useful tool for localizing epileptogenic foci and their associated dynamic deficits.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-198906000-00006