The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

The functionally conserved proteins CBP and p300 act in conjunction with other factors to activate transcription of DNA. A new factor, p/CIP, has been discovered that is present in the cell as a complex with CBP and is required for transcriptional activity of nuclear receptors and other CBP/p300-dep...

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Bibliographic Details
Published in:Nature (London) 1997-06, Vol.387 (6634), p.677-684
Main Authors: Rose, David W, Rosenfeld, Michael G, Torchia, Joseph, Inostroza, Juan, Kamei, Yasutomi, Westin, Stefan, Glass, Christopher K
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Binding Sites
Biological and medical sciences
Cell Line
Cellular biology
CREB-Binding Protein
Deoxyribonucleic acid
DNA
E1A-Associated p300 Protein
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Genes
Genes, Reporter
HeLa Cells
Histone Acetyltransferases
Humans
Interferon-gamma - antagonists & inhibitors
Interferon-gamma - metabolism
Leucine - metabolism
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Nuclear Proteins - metabolism
Nuclear Receptor Coactivator 1
Nuclear Receptor Coactivator 2
Nuclear Receptor Coactivator 3
Protein Binding
Proteins
Rats
Receptors, Cytoplasmic and Nuclear - metabolism
Recombinant Fusion Proteins - genetics
Recombinant Fusion Proteins - metabolism
Saccharomyces cerevisiae
Sequence Homology, Amino Acid
Signal Transduction
Trans-Activators - genetics
Trans-Activators - metabolism
Transcription Factors - genetics
Transcription Factors - metabolism
Transcription. Transcription factor. Splicing. Rna processing
Transcriptional Activation
Tretinoin - antagonists & inhibitors
Tretinoin - metabolism
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Summary:The functionally conserved proteins CBP and p300 act in conjunction with other factors to activate transcription of DNA. A new factor, p/CIP, has been discovered that is present in the cell as a complex with CBP and is required for transcriptional activity of nuclear receptors and other CBP/p300-dependent transcription factors. The highly related nuclear-receptor co-activator protein NCoA-1 is also specifically required for ligand-dependent activation of genes by nuclear receptors. p/CIP, NCoA-1 and CBP all contain related leucine-rich charged helical interaction motifs that are required for receptor-specific mechanisms of gene activation, and allow the selective inhibition of distinct signal-transduction pathways.
ISSN:0028-0836
1476-4687
DOI:10.1038/42652