Initial Genome Scan of the NIMH Genetics Initiative Bipolar Pedigrees: Chromosomes 4, 7, 9, 18, 19, 20, and 21q

An initial genome scan was performed on 540 individuals from 97 families segregating bipolar disorder, collected through the National Institutes of Mental Health Genetics Initiative. We report here affected‐sib‐pair (ASP) data on 126 marker loci (≈68,000 genotypes) mapping to chromosomes 4, 7, 9, 18...

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Bibliographic Details
Published in:American journal of medical genetics 1997-05, Vol.74 (3), p.254-262
Main Authors: Detera-Wadleigh, Sevilla D., Badner, Judith A., Yoshikawa, Takeo, Sanders, Alan R., Goldin, Lynn R., Turner, Gordon, Rollins, Denise Y., Moses, Tracy, Guroff, Juliet J., Kazuba, Diane, Maxwell, Mary E., Edenberg, Howard J., Foroud, Tatiana, Lahiri, Debomoy, Nurnberger Jr, John I., Stine, O. Colin, McMahon, Francis, Meyers, Deborah A., MacKinnon, Dean, Simpson, Sylvia, McInnis, Melvin, DePaulo, J. Raymond, Rice, John, Goate, Alison, Reich, Theodore, Blehar, Mary C., Gershon, Elliot S.
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Alleles
Biological and medical sciences
bipolar disorder
Bipolar Disorder - genetics
Bipolar disorders
bipolar pedigree
Chromosome Mapping
Chromosomes, Human, Pair 18
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 20
Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 7
Chromosomes, Human, Pair 9
Female
Genetic Linkage
Genetic Markers
genome scan
Genome, Human
Genotype
Humans
linkage
Male
Medical sciences
Mood disorders
National Institute of Mental Health (U.S.)
Nuclear Family
Pedigree
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
United States
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Summary:An initial genome scan was performed on 540 individuals from 97 families segregating bipolar disorder, collected through the National Institutes of Mental Health Genetics Initiative. We report here affected‐sib‐pair (ASP) data on 126 marker loci (≈68,000 genotypes) mapping to chromosomes 4, 7, 9, 18, 19, 20, and 21q, under three affection status models. Modest increases in identical‐by‐descent (IBD) allele sharing were found at the following loci: D4S2397 and D4S391 (P < 0.05) on 4p, D4S1647 (P < 0.05) on 4q, D7S1802 and D7S1869 (low P = 0.01) on 7p, D9S302 (P = 0.004) on 9q, and D20S604 on 20p and D20S173 on 20q (P ≤ 0.05). In addition, five markers on 7q displayed increased IBD sharing (P = 0.046–0.002). Additional ASP analyses on chromosomes 18 and 21q marker data were performed using disease phenotype models defined previously. On chromosome 18, only D18S40 on 18p and D18S70 on 18q yielded a slight elevation in allele sharing (P = 0.02), implying that the reported linkages in these regions were not confirmed. On chromosome 21q, a cluster of markers within an ≈9 cM interval: D21S1254, D21S65, D21S1440, and D21S1255 exhibited excess allele sharing (P = 0.041–0.008). Multilocus data on overlapping marker quartets, from D21S1265 to D21S1255, which were consistent with increased IBD sharing (P < 0.01, with a low of 0.0009), overlapped a broad interval of excess allele sharing reported previously, increasing support for a susceptibility locus for bipolar disorder on 21q. Am. J. Med. Genet. 74:254–262, 1997. © 1997 Wiley‐Liss, Inc.
ISSN:0148-7299
1096-8628
DOI:10.1002/(SICI)1096-8628(19970531)74:3<254::AID-AJMG4>3.0.CO;2-Q