Antifungal Diterpenoid Alkaloids from Delphinium denudatum

The roots of Delphinium denudatum have yielded a new diterpenoid alkaloid, 8-acetylheterophyllisine (1), in addition to the known alkaloids vilmorrianone (2), panicutine (3), denudatine (4), isotalatizidine (5), and condelphine (6), as well as 3-hydroxy-2-methyl-4H-pyran-4-one (7). Compounds 1, 3, a...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1997-05, Vol.60 (5), p.472-474
Main Authors: Atta-ur-Rahman, Nasreen, Amber, Akhtar, Farzana, Shekhani, M. Saleh, Clardy, Jon, Parvez, Masood, Choudhary, M. Iqbal
Format: Article
Language:English
Subjects:
3-hydroxy-2-methyl-4h-pyran-4-one
8-acetylheterophyllisine
ALCALOIDE
ALCALOIDES
ALKALOIDS
Alkaloids - isolation & purification
Alkaloids - pharmacology
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
ANTIFUNGAL PROPERTIES
ASPERGILLUS NIGER
Biological and medical sciences
CHEMICAL COMPOSITION
CHEMICAL STRUCTURE
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
condelphine
Crystallography, X-Ray
DELPHINIUM
denudatine
Diterpenes - isolation & purification
Diterpenes - pharmacology
DRUG PLANTS
dutarium rotatum
EPIDERMOPHYTON
EPIDERMOPHYTON FLOCCOSUM
ESPECTROMETRIA
ESTRUCTURA QUIMICA
Fungi - drug effects
General pharmacology
isotalatizidine
KHUSKIA
KHUSKIA ORYZAE
Medical sciences
MICOSIS
Microbial Sensitivity Tests
MYCOSE
MYCOSES
PAKISTAN
panicutine
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
PLANTAS MEDICINALES
PLANTE MEDICINALE
PLEUROTUS OSTREATUS
PROPIEDADES ANTIMICOSICAS
PROPRIETE ANTIFONGIQUE
PSEUDALLESCHERIA
RACINE
RAICES
ROOTS
SPECTRAL ANALYSIS
SPECTROMETRIE
SPECTROMETRY
Spectrophotometry, Ultraviolet
STACHYBOTRYS
STACHYBOTRYS ATRA
STRUCTURE CHIMIQUE
vilmorrianone
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The roots of Delphinium denudatum have yielded a new diterpenoid alkaloid, 8-acetylheterophyllisine (1), in addition to the known alkaloids vilmorrianone (2), panicutine (3), denudatine (4), isotalatizidine (5), and condelphine (6), as well as 3-hydroxy-2-methyl-4H-pyran-4-one (7). Compounds 1, 3, and 7 have not been isolated from this plant previously. The structures of compounds 1, 3, and 7 were determined through spectral and X-ray diffraction analyses. Compounds 1−3 have shown antifungal activity against a number of human pathogenic fungi.
ISSN:0163-3864
1520-6025
DOI:10.1021/np960663n