Intranasal Sendai virus vaccine protects African green monkeys from infection with human parainfluenza virus-type one

Human parainfluenza virus-type 1 (hPIV-1) infections are a common cause of “croup” and hospitalizations among young children. Here we address the possibility of using the xenotropic Sendai virus [a mouse parainfluenza virus (PIV)] as a vaccine for hPIV-1. Sendai virus was administered to six African...

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Bibliographic Details
Published in:Vaccine 1997-04, Vol.15 (5), p.533-540
Main Authors: Hurwitz, Julia L., Soike, Kenneth F., Sangster, Mark Y., Portner, Allen, Sealy, Robert E., Dawson, Dawn H., Coleclough, Christopher
Format: Article
Language:English
Subjects:
Administration, Intranasal
Animals
Antibodies, Viral - biosynthesis
Antibody Specificity
Biological and medical sciences
Cercopithecus aethiops
Fundamental and applied biological sciences. Psychology
Humans
Immunoglobulin A - immunology
Microbiology
Parainfluenza Virus 1, Human
parainfluenza virus-type 1
Respirovirus - immunology
Respirovirus Infections - prevention & control
Sendai virus
vaccine
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Viral Vaccines
Virology
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Summary:Human parainfluenza virus-type 1 (hPIV-1) infections are a common cause of “croup” and hospitalizations among young children. Here we address the possibility of using the xenotropic Sendai virus [a mouse parainfluenza virus (PIV)] as a vaccine for hPIV-1. Sendai virus was administered to six African green monkeys ( Cercopithecus aethiops) by the intranasal (i.n.) route. A long lasting virus-specific antibody response was elicited, both in the serum and nasal cavity. Sendai virus caused no apparent clinical symptoms in the primates, but live virus was detected in the nasal cavity for several days after inoculation. No virus was detected after a second dose of Sendai virus was administered on day 126 after the initial priming. Animals were challenged with hPIV-1 i.n. on day 154. All six vaccinated animals were fully protected from infection while six of six control animals were infected with hPIV-1. The antibody responses induced by Sendai virus immunizations proved to be greater than those induced by hPIV-1. These results demonstrate that unmanipulated Sendai virus is an effective vaccine against hPIV-1 in a primate model and may constitute a practical vaccine for human use.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(97)00217-X