Clinical effects of immunotherapy on Japanese cedar pollinosis in the season of cedar and cypress pollination

Because of cross-allergenicity between Cryptomeria japonica (Japanese cedar) and Chamaecyparis obtusa (Japanese cypress) pollens, many Japanese cedar pollinosis patients have symptoms during the cypress pollination season. Therefore, the effect of immunotherapy (IT) specific for Japanese cedar polli...

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Bibliographic Details
Published in:Auris, nasus, larynx nasus, larynx, 1997-04, Vol.24 (2), p.163-170
Main Authors: Ito, Yukiko, Takahashi, Yukimitsu, Fujita, Tomohiko, Fukuyama, Satoko
Format: Article
Language:English
Subjects:
Adult
Allergens - immunology
Chamaecyparis obtusa
Cross Reactions - immunology
Cryptomeria japonica
Desensitization, Immunologic - methods
Female
Humans
Immunotherapy
Japan
Japanese cedar pollinosis
Male
Middle Aged
Pollen - immunology
Pollination
Rhinitis, Allergic, Seasonal - immunology
Rhinitis, Allergic, Seasonal - therapy
Treatment Outcome
Trees
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Summary:Because of cross-allergenicity between Cryptomeria japonica (Japanese cedar) and Chamaecyparis obtusa (Japanese cypress) pollens, many Japanese cedar pollinosis patients have symptoms during the cypress pollination season. Therefore, the effect of immunotherapy (IT) specific for Japanese cedar pollinosis must be evaluated not only in the cedar season but also in the cypress season. Eight out of 16 patients with cedar pollinosis who received IT and the same number not receiving IT (non-IT) were studied. Nasal and ocular symptoms and medication(s) prescribed were classified from score 0 to 4 and score 0 to 3, respectively. The sum of these scores was used as the symptom-medication score (SMS). IT with Japanese cedar pollen extract reduced the daily SMS not only in cedar but also in the cypress pollination season, but not significantly. However, after the season, the mean SMS in the IT group tended to be lower than that in the non-IT group ( P< 0.1). In conclusion, IT was useful as well as concomitant medications also in the cypress season, and considered to shorten the long-drawn symptoms persisting after the season.
ISSN:0385-8146
1879-1476
DOI:10.1016/S0385-8146(96)00028-4