Lewis, secretor, and ABO phenotypes, and sulfomucin expression in gastric intestinal metaplasia

The closely interrelated Lewis, secretor, and ABO phenotypes have long been linked to the risk of peptic ulcers and gastric cancer and may modulate the interaction between Helicobacter pylori and the gastric surface epithelium. We explored the association between the expression of sulfomucins in gas...

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Bibliographic Details
Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 1997-04, Vol.6 (4), p.287-289
Main Authors: Torrado, J, Ruiz, B, Garay, J, Cosme, A, Arenas, J I, Bravo, J C, Fontham, E, Correa, P
Format: Article
Language:English
Subjects:
ABO Blood-Group System - analysis
Adolescent
Adult
Aged
Biopsy
Colombia
Cross-Cultural Comparison
Female
Gastric Mucosa - pathology
Helicobacter Infections - pathology
Helicobacter pylori
Humans
Lewis Blood-Group System - analysis
Male
Metaplasia
Middle Aged
Mucins - analysis
Phenotype
Precancerous Conditions - pathology
Risk Factors
Spain
Stomach Neoplasms - pathology
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Summary:The closely interrelated Lewis, secretor, and ABO phenotypes have long been linked to the risk of peptic ulcers and gastric cancer and may modulate the interaction between Helicobacter pylori and the gastric surface epithelium. We explored the association between the expression of sulfomucins in gastric intestinal metaplasia, a known marker of preneoplastic progression, and the expression of Lewis, secretor, and ABO phenotypes, in 523 subjects from Nariño, Colombia, and 856 subjects from northern Spain. In both study populations, Lewis (a+/b-) and nonsecretor phenotypes showed a significant positive association with the expression of sulfomucins (odds ratios, 2.4 and 2.6, respectively).
ISSN:1055-9965
1538-7755