Preclinical and clinical studies of a collagen membrane (Bio-Gide ®)

Membranes are used to guide the repopulation of defects by preferred cells and to achieve a specific healing effect. The collagen membrane studied, Bio-Gide ®, was developed particularly for periodontal, peri-implant applications or to improve the ossification of bone defects of any origin. Bio-Gide...

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Bibliographic Details
Published in:Biomaterials 1997-04, Vol.18 (7), p.535-538
Main Authors: Schlegel, A.K., Möhler, H., Busch, F., Mehl, A.
Format: Article
Language:English
Subjects:
Animals
Bio-Gide
Biocompatible Materials
Biological and medical sciences
bone healing
Cattle
Collagen - immunology
Collagen membrane
Enzyme-Linked Immunosorbent Assay
Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics
Humans
immune response
Maxillofacial surgery. Dental surgery. Orthodontics
Medical sciences
Membranes, Artificial
Molar - surgery
Osteogenesis
Rabbits
Random Allocation
Reproducibility of Results
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery, Oral
Swine
Wound Healing
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Summary:Membranes are used to guide the repopulation of defects by preferred cells and to achieve a specific healing effect. The collagen membrane studied, Bio-Gide ®, was developed particularly for periodontal, peri-implant applications or to improve the ossification of bone defects of any origin. Bio-Gide ® is a bilayer membrane; one compact and smooth layer is covered by a particularly dense film, designed to prevent the invasion of soft tissue in a membrane-protected bone defect. The other, rough side of Bio-Gide ® must be placed towards the bone defect in order to make bone ingrowth possible. As a prerequisite for its therapeutic use in humans, the collagen matrix must be devoid of major immunogenicity. The immunological response to the membrane material was analysed in rabbits. Later, a clinical prospective study provided information about the bone regeneration effect under the Bio-Gide ® membrane inserted in six patients selected at random. The immune response to the collagen membrane Bio-Gide ® and the bone healing was tested in these patients when undergoing oral surgery.
ISSN:0142-9612
1878-5905
DOI:10.1016/S0142-9612(96)00175-5