A Family of Novel Macrocyclic Lactones, the Saccharocarcins Produced by Saccharothrix aerocolonigenes subsp. antibiotica: II. Physico-chemical Properties and Structure Determination

Six novel tetronic acid analogs were isolated from the fermentation broth of the actinomycete Saccharothrix aerocolongenes subsp. antibiotica SCC1886. The structures of these saccharocarcins were determined by their spectral data, and chemical degradation. All six compounds are derived from two modi...

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Bibliographic Details
Published in:Journal of antibiotics 1997/02/25, Vol.50(2), pp.126-134
Main Authors: HEGDE, VINOD R., PATEL, MAHESH G., DAS, PRADIP R., PRAMANIK, BIRENDRA, PUAR, MOHINDAR S.
Format: Article
Language:English
Subjects:
Actinomycetales - metabolism
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Antibacterial agents
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Applied microbiology
Biological and medical sciences
Carbohydrate Sequence
Chemical Phenomena
Chemistry, Physical
Fermentation
Fundamental and applied biological sciences. Psychology
Macrolides
Magnetic Resonance Spectroscopy
Medical sciences
Microbiology
Molecular Sequence Data
Molecular Structure
Pharmacology. Drug treatments
Spectrometry, Mass, Fast Atom Bombardment
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Summary:Six novel tetronic acid analogs were isolated from the fermentation broth of the actinomycete Saccharothrix aerocolongenes subsp. antibiotica SCC1886. The structures of these saccharocarcins were determined by their spectral data, and chemical degradation. All six compounds are derived from two modified tetronic acid homologs which differ from other tetronic acids by having an ethyl or propyl side chain at C-23 and a methyl group at C-16. They are all characterized by a novel sugar-amide at C-17.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.50.126