Family history of prostate cancer: A multi‐center case‐control study in Canada

In a population‐based case‐control study of prostate cancer conducted in Montreal, Toronto and Vancouver between 1989 and 1993, a total of 640 newly incident cases and 639 aged‐matched population controls were interviewed as to their family history of prostate cancer as well as nutritional and other...

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Bibliographic Details
Published in:International journal of cancer 1997-03, Vol.70 (6), p.679-681
Main Authors: Ghadirian, P., Howe, G.R., Hislop, T.G., Maisonneuve, P.
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Canada - epidemiology
Case-Control Studies
Cluster Analysis
Diet
Humans
Life Style
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Prostatic Neoplasms - epidemiology
Prostatic Neoplasms - genetics
Risk
Tumors of the urinary system
Urinary tract. Prostate gland
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Summary:In a population‐based case‐control study of prostate cancer conducted in Montreal, Toronto and Vancouver between 1989 and 1993, a total of 640 newly incident cases and 639 aged‐matched population controls were interviewed as to their family history of prostate cancer as well as nutritional and other lifestyle and environmental factors. In total, 94 cases (15%) reported at least one blood relative with a family history, as compared with 32 (5%) of controls, giving a relative risk of 3.32 (95% confidence interval 2.18–5.05). The association was very consistent across all 3 centers, and was similar for each specific type of relative considered (fathers or brothers). Thus, this study provides further evidence of familial aggregation of prostate cancer, and suggests the possibility that part or all of such clustering could be related to inherited genetic patterns; if so, the availability of screening procedures for the disease offers the possibility of useful early intervention in individuals with such inherited susceptibility. Int. J. Cancer 70:679–681, 1997.
ISSN:0020-7136
1097-0215
DOI:10.1002/(SICI)1097-0215(19970317)70:6<679::AID-IJC9>3.0.CO;2-S