Antimicrobial susceptibilities of blood culture isolates obtained before and after the introduction of ciprofloxacin

The in-vitro susceptibilities of 1658 blood culture isolates to ciprofloxacin and 13 other antimicrobial agents were determined, and compared with the results for isolates obtained before and after the availability of ciprofloxacin in 1989. Only six (0.6%) of 995 Enterobacteriaceae were resistant to...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1997-03, Vol.39 (3), p.419-422
Main Authors: PIERONI, P, GOODFELLOW, J, REESOR, L, LOUIE, M, SIMOR, A. E
Format: Article
Language:English
Subjects:
Acinetobacter
Acinetobacter - drug effects
Anti-Infective Agents - blood
Anti-Infective Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteremia - physiopathology
Biological and medical sciences
Ciprofloxacin - blood
Ciprofloxacin - pharmacology
Citrobacter freundii - drug effects
Drug Resistance, Microbial
Enterobacter - drug effects
Enterobacteriaceae
Escherichia coli - drug effects
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Humans
In Vitro Techniques
Klebsiella pneumoniae - drug effects
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Proteus mirabilis - drug effects
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Serratia - drug effects
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Summary:The in-vitro susceptibilities of 1658 blood culture isolates to ciprofloxacin and 13 other antimicrobial agents were determined, and compared with the results for isolates obtained before and after the availability of ciprofloxacin in 1989. Only six (0.6%) of 995 Enterobacteriaceae were resistant to the fluoroquinolones tested; all of the ciprofloxacin-resistant strains were isolated after 1989 (P = 0.04). No significant increase in ciprofloxacin resistance was found in Pseudomonas aeruginosa or Acinetobacter spp. No resistance to ciprofloxacin was found in 124 Staphylococcus aureus isolates prior to 1989, but five (2.4%) of 208 S. aureus strains recovered after 1989 were ciprofloxacin-resistant (P = 0.16). Rates of resistance to ciprofloxacin and other antimicrobial agents commonly used to treat bacteraemic infections have remained relatively low in this Canadian teaching hospital over the past 16 years.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/39.3.419