The palliative therapy of advanced prostate cancer, with particular reference to the results of recent European clinical trials

Summary The palliative therapy of advanced prostate cancer still remains a perplexing problem. If advanced prostate cancer is defined either as a primary advanced‐stage tumour (T3, T4, N0‐N1), or a rising PSA level after primary and hopefully curative therapy, or the traditional patient presenting w...

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Bibliographic Details
Published in:British Journal of Urology 1997-03, Vol.79 (S1), p.72-81
Main Author: NEWLING, D.W.W.
Format: Article
Language:English
Subjects:
Androgen Antagonists - therapeutic use
Castration
Chemotherapy, Adjuvant
Clinical Trials as Topic
Combined Modality Therapy
Estrogens - therapeutic use
Humans
Male
Neoplasm Recurrence, Local - drug therapy
Orchiectomy
Palliative Care - methods
Prostatic Neoplasms - prevention & control
Prostatic Neoplasms - therapy
Time Factors
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Summary:Summary The palliative therapy of advanced prostate cancer still remains a perplexing problem. If advanced prostate cancer is defined either as a primary advanced‐stage tumour (T3, T4, N0‐N1), or a rising PSA level after primary and hopefully curative therapy, or the traditional patient presenting with small‐ or large‐volume metastases with or without symptoms, then some 60% of all patients have advanced disease when first seen. There is still a need for the continuation of large prospective, randomized studies in all stages of this common illness, to define the role of the different therapeutic options at our disposal. The urological and urooncological worlds must be patient and not jump to too many early conclusions over the benefit of the various therapies until a statistical advantage for both individual and combined therapeutic options has been shown.
ISSN:0007-1331
1464-410X
DOI:10.1111/j.1464-410X.1997.tb00805.x