Benzophenone Photoprobes for Phosphoinositides, Peptides and Drugs

Benzophenones (BP) and related aryl ketone photophores have become established as the photoactivatable group of choice for high‐efficiency covalent modification of hydrophobic regions of binding proteins, including enzymes and receptors that recognize peptide hormones, (oligonucleotides and nucleosi...

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Bibliographic Details
Published in:Photochemistry and photobiology 1997-02, Vol.65 (2), p.222-234
Main Authors: Prestwich, Glenn D., Dormán, György, Elliott, John T., Marecak, Dale M., Chaudhary, Anu
Format: Article
Language:English
Subjects:
Affinity Labels - chemical synthesis
Affinity Labels - chemistry
Benzophenones - chemical synthesis
Benzophenones - chemistry
Peptides - analysis
Pharmaceutical Preparations - analysis
Phosphatidylinositols - analysis
Photobiology - methods
Photosensitizing Agents - chemical synthesis
Photosensitizing Agents - chemistry
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Summary:Benzophenones (BP) and related aryl ketone photophores have become established as the photoactivatable group of choice for high‐efficiency covalent modification of hydrophobic regions of binding proteins, including enzymes and receptors that recognize peptide hormones, (oligonucleotides and nucleosides, phosphoinositides, inositol polyphosphates and a wide variety of therapeutic molecules. This review presents the advantages of BP as pho‐toafnnity labels and provides specific examples from the last 3 years of applications of BP‐containing ligands used in biochemistry.
ISSN:0031-8655
1751-1097
DOI:10.1111/j.1751-1097.1997.tb08548.x