Cardiac norepinephrine kinetics in hypertrophic cardiomyopathy

We examined the uptake and release of norepinephrine in the cardiac circulation and other regional vascular beds in 11 patients with hypertrophic cardiomyopathy (HCM) and in 10 control subjects during simultaneous infusion of tracer-labeled norepinephrine and isoproterenol. Cardiac neuronal uptake o...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1989-04, Vol.79 (4), p.836-844
Main Authors: BRUSH, J. E. JR, EISENHOFER, G, GARTY, M, STULL, R, MARON, B. J, CANNON, R. O. III, PANZA, J. A, EPSTEIN, S. E, GOLDSTEIN, D. S
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cardiology. Vascular system
Cardiomyopathy, Hypertrophic - etiology
Cardiomyopathy, Hypertrophic - metabolism
Female
Glycols - biosynthesis
Heart
Humans
Isoproterenol - pharmacokinetics
Male
Medical sciences
Methoxyhydroxyphenylglycol - analogs & derivatives
Methoxyhydroxyphenylglycol - biosynthesis
Middle Aged
Myocarditis. Cardiomyopathies
Myocardium - metabolism
Neurons - metabolism
Norepinephrine - pharmacokinetics
Sympathetic Nervous System - physiopathology
Tritium
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We examined the uptake and release of norepinephrine in the cardiac circulation and other regional vascular beds in 11 patients with hypertrophic cardiomyopathy (HCM) and in 10 control subjects during simultaneous infusion of tracer-labeled norepinephrine and isoproterenol. Cardiac neuronal uptake of norepinephrine was assessed by comparing regional removal of tracer-labeled norepinephrine with that of tracer-labeled isoproterenol (which is not a substrate for neuronal uptake) and by the relation between production of dihydroxyphenylglycol (DHPG), an exclusively intraneuronal metabolite of norepinephrine, and regional spillover of norepinephrine. Cardiac extraction of norepinephrine averaged 59 +/- 17% in the patients with HCM, significantly less than in the control subjects (79 +/- 13%, p less than 0.05), whereas cardiac extraction of isoproterenol was similar in the two groups (13 +/- 23% versus 13 +/- 14%), indicating that neuronal uptake of norepinephrine was decreased in the patients with HCM. The cardiac arteriovenous difference in norepinephrine was significantly larger in the patients with HCM than in the control subjects (73 +/- 77 versus 13 +/- 50 pg/ml, p less than 0.05), as was the product of the arteriovenous difference in norepinephrine and coronary blood flow (7.3 +/- 7.3 versus 0.8 +/- 3.0 ng/min, p less than 0.05).
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.79.4.836