Cardiovascular status after postural change in compensated cirrhosis: an argument for vasodilatory concept

: It seems that hypervolemia and vasodilatation coincide in compensated cirrhosis, but neither rank nor importance of these factors has been fully clarified in adaptive response to postural change. We studied, with gated equilibrium radionuclide angiography and thoracic electrical bioimpedance the h...

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Published in:Liver (Copenhagen) 1997-02, Vol.17 (1), p.1-6
Main Authors: Hartleb, Marek, Rudzki, Krystian, Karpel, Ewa, Becker, Alina, Waluga, Marek, Boldys, Hubert, Nowak, Andrzej, Nowak, Stanislaw
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood Pressure
Cardiac Output - physiology
Cardiography, Impedance
cardiovascular reflexes
cirrhosis
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gated Blood-Pool Imaging
Heart Rate - physiology
Hemodynamics
Humans
Liver Cirrhosis - physiopathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Other diseases. Semiology
postural reflexes
Posture - physiology
Space life sciences
systemic hemodynamics
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Summary:: It seems that hypervolemia and vasodilatation coincide in compensated cirrhosis, but neither rank nor importance of these factors has been fully clarified in adaptive response to postural change. We studied, with gated equilibrium radionuclide angiography and thoracic electrical bioimpedance the hemodynamic status of 19 patients with compensated cirrhosis and 18 healthy subjects in upright and supine positions. In the upright position, the cirrhotic patients were hypotensive and had decreased peripheral vascular resistance despite increased cardiac output. The transition to the supine position was accompanied by a significant fall in the heart rate and an increase in the stroke volume in both controls (92±22 to 63±10 beats/min, and 38±9 to 62±19 ml/m2, respectively) and cirrhotic patients (101±20 to 79±13 beats/min, and 44±15 to 63±19 ml/m2, respectively). Besides, the diastolic arterial pressure fell in controls from 89±9 mmHg to 81 ± 11 mmHg; p
ISSN:0106-9543
1600-0676
DOI:10.1111/j.1600-0676.1997.tb00770.x