Protein Design, a Minimalist Approach

The question of how the amino acid sequence of a protein specifies its three-dimensional structure remains to be answered. Proteins are so large and complex that it is difficult to discern the features in their sequences that contribute to their structural stability and function. One approach to thi...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1989-02, Vol.243 (4891), p.622-628
Main Authors: DeGrado, William F., Wasserman, Zelda R., Lear, James D.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino acid sequencing
Amino acids
Analysis
Aqueous solutions
Atoms
Biological and medical sciences
Biology
Crossovers
Electrostatics
Fundamental and applied biological sciences. Psychology
Globulins
Hydrogen bonds
Ion Channels
Macromolecular Substances
Modeling
Models, Molecular
Molecular biophysics
Molecular structure
Molecules
Protein Conformation
protein engineering
Proteins
Solubility
Structure in molecular biology
Structure-Activity Relationship
Tridimensional structure
Tropomyosin
Water
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The question of how the amino acid sequence of a protein specifies its three-dimensional structure remains to be answered. Proteins are so large and complex that it is difficult to discern the features in their sequences that contribute to their structural stability and function. One approach to this problem is de novo design of model proteins, much simpler than their natural counterparts, yet containing sufficient information in their sequences to specify a given function (for example, folding in aqueous solution, folding in membranes, or formation of ion channels). Designed proteins provide simple model systems for understanding protein structure and function.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.2464850