Repeated interferon-α administration inhibits dopaminergic neural activity in the mouse brain

In vivo effects of single and repeated interferon-α administrations on the dynamics of noradrenaline, dopamine and 5-hydroxytryptamine were investigated in the mouse brain. Single interferon-α administration (15.30 and 60 × 10 6 U/kg i.p.) had no significant effect on the levels of monoamines and th...

Full description

Saved in:
Bibliographic Details
Published in:Brain research 1997-02, Vol.747 (2), p.348-351
Main Authors: Shuto, Hideki, Kataoka, Yasufumi, Horikawa, Tomoko, Fujihara, Narumi, Oishi, Ryozo
Format: Article
Language:English
Subjects:
Animals
Biogenic Monoamines - metabolism
Brain - drug effects
Depression
Dopamine
Dopamine - metabolism
Drug Administration Schedule
Interferon-alpha - pharmacology
Interferon-α
Male
Mice
Mice, Inbred Strains
Norepinephrine - metabolism
Parkinsonism
Serotonin - metabolism
Suicide
Synaptic Transmission - drug effects
Turnover
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In vivo effects of single and repeated interferon-α administrations on the dynamics of noradrenaline, dopamine and 5-hydroxytryptamine were investigated in the mouse brain. Single interferon-α administration (15.30 and 60 × 10 6 U/kg i.p.) had no significant effect on the levels of monoamines and their metabolites or monoamine turnover. When interferon-α (15 × 10 6 U/kg i.p.) was administered once a day for 5 days, however, both dopamine and 3,4-dihydroxyphenylacetic acid levels were significantly decreased and α-methyl- p-tyrosine-induced dopamine depletion was significantly suppressed. These results suggest that repeated interferon-α administration inhibits dopaminergic neural activity. This inhibitory action of interferon-α in dopamine neurons may be involved in adverse central effects, such as parkinsonism and depression with suicidal potential.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(96)01371-6