Adenocarcinoma of the prostate in cystoprostatectomy specimens removed for bladder cancer

The prostate glands of 84 men undergoing cystoprostatectomy for bladder cancer were examined by whole‐mount sections at 4‐mm to 5‐mm intervals to identify unsuspected prostate adenocarcinoma (PCa). Of 72 white patients with entirely normal digital rectal examinations (DRE), 33 (46%) were found to ha...

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Bibliographic Details
Published in:Cancer 1989-01, Vol.63 (2), p.381-385
Main Authors: Montie, James E., Wood, David P., Pontes, J. Edson, Boyett, James M., Levin, Howard S.
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnosis
Adenocarcinoma - epidemiology
Adenocarcinoma - pathology
Aged
Biological and medical sciences
Humans
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Prostatectomy
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - epidemiology
Prostatic Neoplasms - pathology
Tumors of the urinary system
Urinary Bladder Neoplasms - surgery
Urinary tract. Prostate gland
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Summary:The prostate glands of 84 men undergoing cystoprostatectomy for bladder cancer were examined by whole‐mount sections at 4‐mm to 5‐mm intervals to identify unsuspected prostate adenocarcinoma (PCa). Of 72 white patients with entirely normal digital rectal examinations (DRE), 33 (46%) were found to have PCa, including 12 (17%) who had a Gleason score of 6 or greater and seven (10%) who had penetration through the prostatic capsule. These observations are consistent with previous studies in autopsy populations but allow a more appropriate comparison with morphologic data generated from radical prostatectomy specimens. If these data can be extended to the age‐matched general population, treatment at a 1% mortality rate for all white men 60 to 74 years of age with a PCa with a Gleason score of 6 or greater could cause between 6190 and 30,951 deaths, in contrast to 7335 deaths expected from the cancer. These data stress the need for a control group in a study designed to evaluate the benefit of early diagnosis and treatment of PCa.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19890115)63:2<381::AID-CNCR2820630230>3.0.CO;2-O