Morphometric changes seen in balloon-injured porcine iliac arteries: the influence of sympathectomy on intimal hyperplasia and remodelling

To assess the influence of lumbar sympathectomy on intimal thickening and arterial remodelling following balloon de-endothelialisation. Experimental animal model with control and treated (sympathectomy) groups. Unilateral common iliac artery de-endothelialisation was performed in 36 male pigs using...

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Bibliographic Details
Published in:European journal of vascular and endovascular surgery 1997-01, Vol.13 (1), p.43-47
Main Authors: Lamawansa, M D, Wysocki, S J, House, A K, Norman, P E
Format: Article
Language:English
Subjects:
Angioplasty, Balloon - adverse effects
Animals
Dilatation, Pathologic - prevention & control
Dilatation, Pathologic - therapy
Endothelium, Vascular - pathology
Hyperplasia
Iliac Artery - injuries
Iliac Artery - pathology
Iliac Artery - physiopathology
Lumbosacral Region
Male
Necrosis
Pilot Projects
Swine
Sympathectomy
Tunica Intima - pathology
Tunica Intima - physiopathology
Wound Healing - physiology
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Summary:To assess the influence of lumbar sympathectomy on intimal thickening and arterial remodelling following balloon de-endothelialisation. Experimental animal model with control and treated (sympathectomy) groups. Unilateral common iliac artery de-endothelialisation was performed in 36 male pigs using a 5F balloon catheter introduced via the profunda femoris artery. Bilateral lumbar sympathectomies were performed in 18 animals. Both iliac arteries were perfusion-fixed and harvested 4 weeks later. Arterial morphometry was assessed using computer image analysis. Area measurements are expressed as median (interquartile range) in mm2. Balloon injury resulted in significant intimal thickening but no loss of lumen due to compensatory enlargement of the injured artery. Sympathectomy resulted in significant lumen enlargement (4.8 (2.6-6.3) vs. 1.9 (1.7-2.9)) in balloon-injured arteries. Although intimal thickening was reduced (0.9 (0.6-1.7) vs. 1.5 (0.9-2.0)), this was not statistically significant. Sympathectomy increases lumen area 4 weeks after balloon injury to porcine iliac arteries. This effect is due to a combination of reduced arterial wall thickening and increased arterial size.
ISSN:1078-5884
1532-2165
DOI:10.1016/S1078-5884(97)80049-4