DNA ploidy, grade, and stage in prognosis of uterine cervical cancer

A retrospective study of 56 cases of uterine cervical squamous carcinoma evaluated DNA content, histological grade, and clinical stage as indicators of prognosis. Minimum survivor follow-up was 24 months. Following standard radiation therapy, there were 40 cures and 16 treatment failures. DNA conten...

Full description

Saved in:

Bibliographic Details
Published in:	Gynecologic oncology 1989, Vol.32 (1), p.4-7
Main Authors:	Davis, John R., Aristizabal, Silvio, Way, Dennis L., Weiner, Sheldon A., Hicks, Mary J., Hagaman, Roberta M.
Format:	Article
Language:	eng
Subjects:	Adult Aged Aged, 80 and over Aneuploidy Biological and medical sciences Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - radiotherapy Diploidy DNA, Neoplasm - analysis Female Female genital diseases Flow Cytometry - methods Follow-Up Studies Gynecology. Andrology. Obstetrics Humans Medical sciences Middle Aged Neoplasm Staging Prognosis Retrospective Studies Tumors Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - radiotherapy
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	A retrospective study of 56 cases of uterine cervical squamous carcinoma evaluated DNA content, histological grade, and clinical stage as indicators of prognosis. Minimum survivor follow-up was 24 months. Following standard radiation therapy, there were 40 cures and 16 treatment failures. DNA content was measured by flow cytometry of pretreatment biopsies removed from paraffin. There were 18 diploid cases and 38 aneuploid (67.9%). Aneuploid cases included 6 with very high G2-M peaks ( $ ̆ 15% of the cell sample). DNA ploidy correlation with prognosis was not statistically significant. However, both grading by a multiple parameter method ( P < 0.0133) and staging ( P < 0.0064) were significant prognostic factors. Higher grade and stage correlated with treatment failure.
ISSN:	0090-8258 1095-6859