Green tea consumption and the risk of pancreatic and colorectal cancers

The effect of green tea drinking in reducing human cancer risk is unclear, though a protective effect has been reported in numerous animal studies and several epidemiologic investigations. Herein the hypothesis that green tea consumption may reduce the risk of cancers of the colon, rectum and pancre...

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Bibliographic Details
Published in:International journal of cancer 1997-01, Vol.70 (3), p.255-258
Main Authors: Ji, Bu‐Tian, Chow, Wong‐Ho, Hsing, Ann Wu, McLaughlin, Joseph K., Dai, Qi, Gao, Yu‐Tang, Blot, William J., Fraumeni, Joseph F.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Case-Control Studies
China - epidemiology
Colonic Neoplasms - epidemiology
Female
Foods and miscellaneous
Humans
Male
Medical sciences
Middle Aged
Pancreatic Neoplasms - epidemiology
Rectal Neoplasms - epidemiology
Risk Factors
Sex Factors
Tea
Tumors
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Summary:The effect of green tea drinking in reducing human cancer risk is unclear, though a protective effect has been reported in numerous animal studies and several epidemiologic investigations. Herein the hypothesis that green tea consumption may reduce the risk of cancers of the colon, rectum and pancreas is examined in a large population‐based case‐control study conducted in Shanghai, China. Newly diagnosed cancer cases (931 colon, 884 rectum and 451 pancreas) during 1990–1993 among residents 30–74 years of age were included. Controls (n = 1,552) were selected among Shanghai residents and frequency‐matched to cases by gender and age. Multivariate odds ratios (ORs) and 95% confidence intervals (Cls) of each cancer associated with green tea consumption were derived after adjustment for age, income, education and cigarette smoking. Additional adjustment for dietary items and body size was found to have minimal impact. An inverse association with each cancer was observed with increasing amount of green tea consumption, with the strongest trends for rectal and pancreatic cancers. For men, compared with non‐regular tea drinkers, ORs among those in the highest tea consumption category (≥300 g/month) were 0.82 for colon cancer, 0.72 for rectal cancer and 0.63 for pancreatic cancer, with p values for trend being 0.38, 0.04 and 0.04, respectively. For women, the respective ORs for the highest consumption category (≥200 g/month) were 0.67, 0.57 and 0.53, with the respective p values for trend being 0.07, 0.001 and 0.008. Our findings provide further evidence that green tea drinking may lower the risk of colorectal and pancreatic cancers. Int. J. Cancer, 70:255–258, 1997. © 1997 Wiley‐Liss, Inc. This article is a US Government work and, as such, is in the public domain in the United States of America.
ISSN:0020-7136
1097-0215
DOI:10.1002/(SICI)1097-0215(19970127)70:3<255::AID-IJC1>3.0.CO;2-W