Pharmacokinetics of a new nitroderivative of acetylsalicylic acid after a single dose in rats

The pharmacokinetics of a new ASA-nitroderivative compound, NCX 4016 (ASA-NO2), was evaluated using an HPLC method. After single equimolar doses of ASA (35 mg kg(-1)) or ASA-NO2 (65 mg kg(-1)), no detectable levels of these compounds have been observed in rat plasma samples. SA peak levels were obta...

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Bibliographic Details
Published in:Life sciences (1973) 1997, Vol.60 (2), p.101-106
Main Authors: Tagliaro, F, Cuzzolin, L, Adami, A, Scarcella, D, Crivellente, F, Benoni, G
Format: Article
Language:English
Subjects:
Animals
Aspirin - administration & dosage
Aspirin - blood
Aspirin - pharmacokinetics
Chromatography, High Pressure Liquid
Female
Rats
Rats, Sprague-Dawley
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Summary:The pharmacokinetics of a new ASA-nitroderivative compound, NCX 4016 (ASA-NO2), was evaluated using an HPLC method. After single equimolar doses of ASA (35 mg kg(-1)) or ASA-NO2 (65 mg kg(-1)), no detectable levels of these compounds have been observed in rat plasma samples. SA peak levels were obtained at 3 h and 6 h after ASA and ASA-NO2 administration respectively. The elimination rate constants of SA were similar after ASA and ASA-NO2, suggesting a similar elimination phase of this metabolite in rats. From these data it is evident that ASA-NO2 is slowly metabolized in ASA, which is rapidly converted to SA.
ISSN:0024-3205
1879-0631