Comparative analysis of anxiety-like behavior in partition and plus-maze tests after agonistic interactions in mice

The behavior of C57BL/6J male mice with experience of repeated victories (winners) or defeats (losers) in daily agonistic interactions, was examined in the plus-maze and partition tests. The latter procedure assesses the reactivity of mice to another conspecific in the neighboring compartment of a c...

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Bibliographic Details
Published in:Physiology & behavior 1997, Vol.61 (1), p.37-43
Main Authors: Avgustinovich, Damira F., Gorbach, Olga V., Kudryavtseva, Natalia N.
Format: Article
Language:eng ; rus
Subjects:
Agonistic Behavior
Agonistic interactions
Animal Communication
Animals
Anxiety
Anxiety - psychology
Arousal
Defeats
Disease Models, Animal
Dominance-Subordination
Escape Reaction
Male
Maze Learning
Mice
Mice, Inbred C57BL
Partition test
Plus-maze test
Social Behavior
Social Environment
Victories
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Summary:The behavior of C57BL/6J male mice with experience of repeated victories (winners) or defeats (losers) in daily agonistic interactions, was examined in the plus-maze and partition tests. The latter procedure assesses the reactivity of mice to another conspecific in the neighboring compartment of a common cage, communicative behavior or level of sociability. The behavior of mice after 10 days (T10) and 20 days (T20) of agonistic confrontations, as well as in controls (5 days of individual housing) was analyzed. Significant differences were found between T10 and T20 losers and controls in both tests. In the partition test, a decrease in the number of approaches and total and average time spent near the partition was found in T10 and, more pronounced, in T20 losers. In the plus-maze, losers showed fewer open and total entries than controls. Moreover, rarely did they pass from one enclosed arm to another, and also showed a decreased number of ‘peepings’ from enclosed arms. Percentage of open time did not differ significantly in losers compared to controls. It is suggested that the level of losers' sociability, estimated as low by the partition test, can include anxiety as a component, which is confirmed, at least partly, by some parameters of the plus-maze test. There were no differences in the partition or plus-maze tests between T10 winners and controls. However, all parameters of partition behavior were significantly different between T20 winners and controls. In the plus-maze, similar to losers, T20 winners displayed fewer open arm entries, number of ‘peepings’, and passages than controls. It was concluded that parameters of the partition and plus-maze tests correlate in mice with the alternative experience of agonistic confrontations, positive or negative. A combination of these two tests may be used for estimation of developing anxiety in mice.
ISSN:0031-9384
1873-507X
DOI:10.1016/S0031-9384(96)00303-4