Effect of Gallium Nitrate Therapy on Ga-67 Scintigraphic Detection of Lymphoma:: Case Report

Ga-67 and abdominal CT scans of a 72-year-old woman who had malignant lymphoma before, during, and after gallium nitrate/hydroxyurea combination therapy are presented. Disappearance of Ga-67 uptake by the tumor during this treatment despite continuing CT evidence of disease and reappearance of Ga-67...

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Bibliographic Details
Published in:Clinical nuclear medicine 1997-01, Vol.22 (1), p.21-24
Main Authors: AKANSEL, GUR, LIU, YU, CHITAMBAR, CHRISTOPHER R, KITAPCI, MEHMET T, AKANSEL, SERTAC, KRASNOW, ARTHUR Z, ISITMAN, ALI T, COLLIER, B DAVID
Format: Article
Language:English
Subjects:
Aged
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Blood cells
Female
Gallium - administration & dosage
Gallium - therapeutic use
Gallium Radioisotopes
Hematologic and hematopoietic diseases
Humans
Hydroxyurea - administration & dosage
Hydroxyurea - therapeutic use
Investigative techniques, diagnostic techniques (general aspects)
Leukemia, Lymphocytic, Chronic, B-Cell - diagnostic imaging
Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Radionuclide Imaging
Radionuclide investigations
Tomography, X-Ray Computed
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Description
Summary:Ga-67 and abdominal CT scans of a 72-year-old woman who had malignant lymphoma before, during, and after gallium nitrate/hydroxyurea combination therapy are presented. Disappearance of Ga-67 uptake by the tumor during this treatment despite continuing CT evidence of disease and reappearance of Ga-67 scan abnormalities after cessation of therapy suggests that caution should be exercised when interpreting results of Ga-67 scintigraphy for the detection of tumor viability during gallium nitrate/hydroxyurea therapy.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-199701000-00005