Protein synthesis assessed by ribosome analysis in human papillary muscle in relation to oxidative capacity: a comparison with skeletal muscle

Protein synthesis as assessed by the concentration and size distribution of ribosomes was determined together with citrate synthase activity in papillary muscles obtained at open heart surgery from patients with mitral valve disease. The results were compared with corresponding data from the quadric...

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Bibliographic Details
Published in:Cardiovascular research 1988-08, Vol.22 (8), p.562-565
Main Authors: WERNERMAN, JAN, SYLVÉN, CHRISTER, VON DER DECKEN, ALEXANDRA, JANSSON, EVA, BÖÖK, KIM, VINNARS, ERIK
Format: Article
Language:English
Subjects:
Biological and medical sciences
Citrate (si)-Synthase - metabolism
citrate synthase
DNA - analysis
Fundamental and applied biological sciences. Psychology
Heart
Humans
Muscle Proteins - biosynthesis
Muscles - metabolism
papillary muscle
Papillary Muscles - cytology
Papillary Muscles - enzymology
Papillary Muscles - metabolism
Polyribosomes
protein synthesis
ribosomes
Ribosomes - metabolism
skeletal muscle
Vertebrates: cardiovascular system
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Summary:Protein synthesis as assessed by the concentration and size distribution of ribosomes was determined together with citrate synthase activity in papillary muscles obtained at open heart surgery from patients with mitral valve disease. The results were compared with corresponding data from the quadriceps femoris muscle of patients undergoing cholecystectomy. Citrate synthase activity was six times higher in papillary muscle than in skeletal muscle. The total ribosome concentration per mg DNA was similar in the two types of muscle. Compared with skeletal muscle, in papillary muscle polyribosomes constituted a higher proportion of the ribosomes (p
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/22.8.562