Analysis of the biocompatibility of ALCAP ceramics in rat femurs

Ceramics composed of aluminum, calcium, and phosphorus oxides (ALCAP) were tested for compatibility as bone replacement biomaterials. Implantation of ALCAP ceramics in rat femurs had no deleterious effect on body weights, organ/body weight ratios, muscle, bone, blood, and kidney function. Aluminum r...

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Bibliographic Details
Published in:Journal of biomedical materials research 1988-12, Vol.22 (12), p.1101-1126
Main Authors: Mattie, D. R., Bajpai, P. K.
Format: Article
Language:English
Subjects:
Alkaline Phosphatase - analysis
Aluminum - urine
Animals
Biocompatible Materials
Biological and medical sciences
Body Weight
Bone and Bones - surgery
Calcium - urine
Calcium Compounds
Ceramics
Female
Femur
Hydroxyproline - urine
Male
Medical sciences
Organ Size
Oxides
Phosphorus - urine
Phosphorus Compounds
Prostheses and Implants
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Rats
Rats, Inbred Strains
Reference Values
Space life sciences
Technology. Biomaterials. Equipments. Material. Instrumentation
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Summary:Ceramics composed of aluminum, calcium, and phosphorus oxides (ALCAP) were tested for compatibility as bone replacement biomaterials. Implantation of ALCAP ceramics in rat femurs had no deleterious effect on body weights, organ/body weight ratios, muscle, bone, blood, and kidney function. Aluminum resorbed from ALCAP ceramic bone implants was excreted in the urine and was not deposited in adjacent muscle. Plasma levels of aluminum were not elevated in rats implanted with ALCAP ceramics. Alkaline phosphatase activity of excised implant sites indicated greater bone formation in ALCAP ceramic implants than in bone autografts. Radiographs and implant histology demonstrated excellent bone association with implants and ingrowth of new bone into ALCAP ceramic implants. ALCAP ceramics are biocompatible and suitable for reconstruction of bone.
ISSN:0021-9304
1097-4636
DOI:10.1002/jbm.820221205