Validation of Recursive Partitioning Analysis Classification in Patients with Brain Metastases from Non-small Cell Lung Cancer Treated with Short-course Accelerated Radiotherapy

Abstract Aims To study various prognostic factors affecting outcome and to validate Radiation Therapy Oncology Group recursive partitioning analysis (RPA) class in non-small cell lung cancer (NSCLC) with brain metastases treated with short-course accelerated radiotherapy (SCAR). Materials and method...

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Bibliographic Details
Published in:Clinical oncology (Royal College of Radiologists (Great Britain)) 2010-12, Vol.22 (10), p.837-843
Main Authors: Agarwal, J.P, Wadasadawala, T, Munshi, A, Chadda, P, Apsani, R, Upasani, M, Laskar, S.G, Pramesh, C.S, Karimundackal, G, Menon, H, Prabhash, K, Jambhekar, N
Format: Article
Language:English
Subjects:
Adult
Aged
Brain metastases
Brain Neoplasms - radiotherapy
Brain Neoplasms - secondary
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - radiotherapy
Carcinoma, Non-Small-Cell Lung - secondary
Cohort Studies
Female
Hematology, Oncology and Palliative Medicine
Humans
Lung Neoplasms - pathology
Lung Neoplasms - radiotherapy
Male
Middle Aged
non-small cell lung cancer
Prognosis
Radiology
Radiotherapy Dosage
recursive partitioning analysis
Retrospective Studies
short-course radiotherapy
Survival Analysis
Treatment Outcome
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Summary:Abstract Aims To study various prognostic factors affecting outcome and to validate Radiation Therapy Oncology Group recursive partitioning analysis (RPA) class in non-small cell lung cancer (NSCLC) with brain metastases treated with short-course accelerated radiotherapy (SCAR). Materials and methods The case records of 100 patients with NSCLC consecutively treated at Tata Memorial Hospital from August 2006 to August 2009 were studied for various patient, tumour and treatment-related prognostic factors. Patients received whole-brain radiotherapy to a dose of 20 Gy/five fractions over 1 week ( n = 90) or 30 Gy/10 fractions over 2 weeks ( n = 10). The Kaplan–Meier estimate was used for survival analysis in SPSS v15. Results The median overall survival was 4.0 months (range 0.5–30.0 months). The 6-, 12-, 18- and 24-month survival rates were 35.8, 18.0, 9.3 and 6.2%, respectively. Of the various prognostic factors, RPA class (II versus III, P value = 0.023), Karnofsky performance score (
ISSN:0936-6555
1433-2981
DOI:10.1016/j.clon.2010.05.022