Aggressive versus conventional strategies in the treatment of rectal adenocarcinoma

Objective: Comparison of an aggressive approach (including total mesorectal excision and combined modality adjuvant therapy) with a conventional approach in the treatment of primary rectal cancer. Design: Retrospective study. Setting: Memorial Sloan-Kettering Cancer Centre, New York (MSKCC) and Univ...

Full description

Saved in:
Bibliographic Details
Published in:Surgical oncology 1996-08, Vol.5 (4), p.183-188
Main Authors: Havenga, K., Huang, Y., Enker, W.E., Welvaart, K., De Roy Van Zuidewijn, D.B.W., Cohen, A.M.
Format: Article
Language:English
Subjects:
Adenocarcinoma - mortality
Adenocarcinoma - therapy
Aged
Aged, 80 and over
Chemotherapy, Adjuvant
Combined Modality Therapy
Disease-Free Survival
Female
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
Radiotherapy, Adjuvant
rectal adenocarcinoma
Rectal Neoplasms - mortality
Rectal Neoplasms - therapy
Retrospective Studies
Survival Rate
total mesorectal excision
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: Comparison of an aggressive approach (including total mesorectal excision and combined modality adjuvant therapy) with a conventional approach in the treatment of primary rectal cancer. Design: Retrospective study. Setting: Memorial Sloan-Kettering Cancer Centre, New York (MSKCC) and University Hospital Leiden, the Netherlands (UHL). Subjects: One hundred and sixty-nine patients treated at MSKCC and 96 patients treated at UHL. Interventions: Total mesorectal excision (MSKCC) and conventional resection (UHL). Main outcome measures: Overall survival and local recurrence-free survival. Results: Five-year overall survival was 73% for MSKCC patients and 52% for UHL patients [ P < 0.001). Five-year local recurrence-free survival was 83% for MSKCC patients and 72% for UHL patients ( P = 0.001). Relative risk of dying or developing a local recurrence was 3.37 and 2.61, respectively, for patients treated at UHL compared to patients treated at MSKCC ( P < 0.001 and P = 0.008, respectively). Conclusions: These data suggest that an aggressive approach including total mesorectal excision and combined modality adjuvant therapy improves survival and local control compared to a conventional approach.
ISSN:0960-7404
1879-3320
DOI:10.1016/S0960-7404(96)80042-9