Reinfection in lyme borreliosis

Two patients with reinfection of Borrelia burgdorferi are presented. An 11-year-old girl developed recurrent acute peripheral facial palsy at an interval of five years. A 64-year-old woman showed paraesthesia in the leg and effusion in the knee. Three years later, an erythema migrans developed at th...

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Bibliographic Details
Published in:Infection 1996-11, Vol.24 (6), p.437-439
Main Authors: EIFFERT, H, HANEFELD, F, THOMSSEN, R, CHRISTEN, H.-J
Format: Article
Language:English
Subjects:
Acute Disease
Antibodies, Bacterial - blood
Bacterial diseases
Biological and medical sciences
Borrelia burgdorferi Group - immunology
Borrelia infections
Child
Facial Paralysis - microbiology
Female
Human bacterial diseases
Humans
Immunoglobulin G - blood
Immunoglobulin M - blood
Infectious diseases
Lyme Disease - complications
Lyme Disease - immunology
Medical sciences
Middle Aged
Paresthesia - microbiology
Recurrence
Time Factors
Tropical bacterial diseases
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Summary:Two patients with reinfection of Borrelia burgdorferi are presented. An 11-year-old girl developed recurrent acute peripheral facial palsy at an interval of five years. A 64-year-old woman showed paraesthesia in the leg and effusion in the knee. Three years later, an erythema migrans developed at the thigh. In both patients tick bites, corresponding clinical manifestations, and detection of specific antibodies proved the reinfections. The course of the humoral immune responses showed basic differences between the patients. At the interval between the first and second infection, the specific antibodies of the girl decreased beyond the cut-off level. On the other hand, the titer of specific IgG antibodies of the other patient remained at a constant level. Reasons for the failure of immune protection are discussed.
ISSN:0300-8126
1439-0973
DOI:10.1007/BF01713045