Cloning and Characterization of Two Novel Human cDNAs (NELL1 and NELL2) Encoding Proteins with Six EGF-like Repeats

From a human fetal-brain cDNA library we isolated two novel genes encoding peptides containing six EGF-like repeats. Both showed significant homologies with nel, a gene strongly expressed in neural tissues of chicken. The cDNAs, designated NELL1 (nel-like, type 1) and NELL2 (nel-like, type 2), conta...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 1996-12, Vol.38 (3), p.273-276
Main Authors: Watanabe, Takeshi K., Katagiri, Toyomasa, Suzuki, Mikio, Shimizu, Fumio, Fujiwara, Tsutomu, Kanemoto, Naohide, Nakamura, Yusuke, Hirai, Yoshikatsu, Maekawa, Hiroumi, Takahashi, Ei-ichi
Format: Article
Language:English
Subjects:
Adult
Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
Brain - embryology
Brain - metabolism
Chickens - genetics
Chromosomes, Human, Pair 11 - genetics
Chromosomes, Human, Pair 12 - genetics
Cloning, Molecular
DNA, Complementary - genetics
Epidermal Growth Factor - chemistry
Fetal Proteins - genetics
Fetus - metabolism
Fundamental and applied biological sciences. Psychology
Genes. Genome
Humans
In Situ Hybridization, Fluorescence
Kidney - embryology
Kidney - metabolism
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Nerve Tissue Proteins - genetics
Open Reading Frames
Sequence Homology, Amino Acid
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Summary:From a human fetal-brain cDNA library we isolated two novel genes encoding peptides containing six EGF-like repeats. Both showed significant homologies with nel, a gene strongly expressed in neural tissues of chicken. The cDNAs, designated NELL1 (nel-like, type 1) and NELL2 (nel-like, type 2), contained open reading frames encoding 810 and 816 amino acids, respectively. NELL2 is strongly expressed in brain of adult and fetus but only weakly in fetal kidney. NELL1 and NELL2 were mapped by FISH to chromosomal bands 11p15.1–p15.2 and 12q13.11–q13.12, respectively.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1996.0628