A comparison of the effects of propofol-alfentanil versus isoflurane anesthesia on arterial oxygenation during one-lung ventilation

To determine whether intravenous propofol-alfentanil anesthesia provides superior arterial oxygenation (Pao2) during one-lung ventilation (OLV) compared with isoflurane inhalation anesthesia. A prospective, randomized, cross-over study. Tertiary-care university hospital. Thirty adults having either...

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Bibliographic Details
Published in:Journal of cardiothoracic and vascular anesthesia 1996-12, Vol.10 (7), p.860-863
Main Authors: Reid, Craig W., Slinger, Peter D., Lenis, Serge
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
alfentanil
Alfentanil - administration & dosage
Anesthesia
Anesthetics, Inhalation - pharmacology
Anesthetics, Intravenous - administration & dosage
Anesthetics. Neuromuscular blocking agents
Arteries
Biological and medical sciences
Cross-Over Studies
Humans
Hydrogen-Ion Concentration
isoflurane
Isoflurane - pharmacology
Medical sciences
Middle Aged
Neuropharmacology
one-lung ventilation
Oxygen - blood
Pharmacology. Drug treatments
propofol
Propofol - administration & dosage
Prospective Studies
Ventilators, Mechanical
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Summary:To determine whether intravenous propofol-alfentanil anesthesia provides superior arterial oxygenation (Pao2) during one-lung ventilation (OLV) compared with isoflurane inhalation anesthesia. A prospective, randomized, cross-over study. Tertiary-care university hospital. Thirty adults having either thoracoscopic pulmonary surgery or esophageal surgery. Patients received either propofol-alfentanil infusion anesthesia or one minimum alveolar concentration (MAC) of isoflurane during the initial period of two-lung ventilation and the first 30 minutes of OLV and then were switched to the other anesthetic for the duration of OLV. Arterial blood gases and hemodynamics were recorded during two-lung ventilation and after 20 and 30 minutes of OLV with each anesthetic technique. The mean values (±SD) for Pao2 during propofol-alfentanil anesthesia after 20 minutes (222 ± 100) and 30 minutes (228 ± 102 mmHg) of one-lung ventilation were not significantly different than after 20 minutes (213 ± 99) or 30 minutes (214 ± 96 mmHg) of isoflurane; beta error less than 0.1. Mean heart rate was lower during intravenous (78 ± 15 min) than inhalation (85 ± 17 min) anesthesia (p = 0.03). This study does not support the theory that total intravenous anesthesia will decrease the risk of hypoxemia during OLV.
ISSN:1053-0770
1532-8422
DOI:10.1016/S1053-0770(96)80046-2