Are particular Epstein–Barr virus strains linked to disease?

The presence of the well-established EBV types (type 1 and 2) in cancers seems merely to reflect their prevalence in the population; the EBNA genes which determine type 1 and 2 are not usually expressed in cancers. In contrast, LMP1 is frequently expressed in nasopharyngeal carcinoma and a variant f...

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Bibliographic Details
Published in:Seminars in cancer biology 1996-08, Vol.7 (4), p.209-215
Main Authors: Jenkins, Peter J., Farrell†, Paul J.
Format: Article
Language:English
Subjects:
Burkitt's lymphoma
Carrier State - ethnology
Defective Viruses - genetics
EBNA
Epstein-Barr virus
Epstein-Barr Virus Nuclear Antigens - genetics
Gene Deletion
Genes, Viral - genetics
Herpesvirus 4, Human - classification
Herpesvirus 4, Human - genetics
Herpesvirus 4, Human - pathogenicity
Humans
LMP1
nasopharyngeal carcinoma
Oncogene Proteins, Viral - genetics
Oncogene Proteins, Viral - physiology
Polymorphism, Genetic
Species Specificity
Viral Matrix Proteins - genetics
Viral Matrix Proteins - physiology
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Summary:The presence of the well-established EBV types (type 1 and 2) in cancers seems merely to reflect their prevalence in the population; the EBNA genes which determine type 1 and 2 are not usually expressed in cancers. In contrast, LMP1 is frequently expressed in nasopharyngeal carcinoma and a variant form of LMP1 has been linked with this disease. This form of LMP1 is also more transforming in cell culture assays. Many other examples of minor sequence variation have been reported but there is no evidence that they are of functional importance in EBV-associated disease.
ISSN:1044-579X
1096-3650
DOI:10.1006/scbi.1996.0028