Temporal dissociation of neurotensin/neuromedin N mRNA expression in topographically separate subsets of rat striatal neurons following administration of haloperidol

The expression of the neurotensin/neuromedin N gene in the rat caudate-putamen was studied at 7 and 24 h following the administration of haloperidol using a riboprobe and non-isotopic in situ hybridization histochemistry. As has been reported by others, expression of neurotensin/neuromedin N mRNA in...

Full description

Saved in:
Bibliographic Details
Published in:Brain research. Molecular brain research. 1996-11, Vol.42 (1), p.71-78
Main Authors: Zahm, Daniel S., Williams, Evelyn S., Poulad, David, Krause, James E.
Format: Article
Language:English
Subjects:
Animals
Antipsychotic Agents - pharmacology
Biological and medical sciences
Brain Mapping
Caudate-putamen
Corpus Striatum - cytology
Corpus Striatum - drug effects
Corpus Striatum - metabolism
Dopamine
Haloperidol - pharmacology
Histocytochemistry - methods
Hybridization, in situ
In Situ Hybridization
Male
Medical sciences
Neuroleptic
Neurons - drug effects
Neurons - metabolism
Neuropharmacology
Neurotensin - genetics
Peptide Fragments - genetics
Peptide regulation
Pharmacology. Drug treatments
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Sprague-Dawley
RNA, Messenger - biosynthesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The expression of the neurotensin/neuromedin N gene in the rat caudate-putamen was studied at 7 and 24 h following the administration of haloperidol using a riboprobe and non-isotopic in situ hybridization histochemistry. As has been reported by others, expression of neurotensin/neuromedin N mRNA in the dorsolaterl quadrant of caudate-putamen was undetectable in controls, robust at 7 h and minimally detectable at 24 h following haloperidol administration. In the dorsomedial and ventrolateral quadrants of the caudate-putamen, barely detectable basal expression of neurotensin/neuromedin N mRNA observed in controls was conspicuously enhanced at 24 h following administration of haloperidol both in terms of numbers of hybridized neurons, which were about 200% of control values, and the amount of chromogen accumulated over individual neurons. The data are consistent with at least two subpopulations of caudate-putamen neurons in which neurotensin/neuromedin N mRNA expression is differentially regulated in response to haloperidol administration.
ISSN:0169-328X
1872-6941
DOI:10.1016/S0169-328X(96)00116-7