A mechanosensitive ion channel in the yeast plasma membrane

Mechanosensitive ion channels use mechanical energy to gate the dissipation of electrochemical gradients across cell membranes. This function is fundamental to physiological processes such as hearing and touch. In electrophysiological studies of ion channels in the plasma membrane of the yeast Sacch...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1988-11, Vol.242 (4879), p.762-765
Main Authors: Gustin, M.C, Zhou, X.L, Martinac, B, Kung, C
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Animal cells
Anions - physiology
Biochemistry
BIOLOGIA MOLECULAR
Biological and medical sciences
BIOLOGIE MOLECULAIRE
Cations
Cations - physiology
Cell Membrane - physiology
Cell Membrane Permeability
Cell membranes
Electric current
Electric potential
electrophysiology
ESTRUCTURA CELULAR
Fundamental and applied biological sciences. Psychology
Growth, nutrition, metabolism, transports, enzymes. Molecular biology
Hydrostatic Pressure
ION
Ion channels
Ion Channels - physiology
IONES
ions
Membrane Potentials
Membrane proteins
Microbiology
Mycology
Patch clamp techniques
Pipettes
plasma membranes
SACCHAROMYCES CEREVISIAE
Saccharomyces cerevisiae - physiology
Space life sciences
Spheroplasts
STRUCTURE CELLULAIRE
Surface Tension
Water-Electrolyte Balance
Yeasts
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Summary:Mechanosensitive ion channels use mechanical energy to gate the dissipation of electrochemical gradients across cell membranes. This function is fundamental to physiological processes such as hearing and touch. In electrophysiological studies of ion channels in the plasma membrane of the yeast Saccharomyces cerevisiae, channels were observed that were activated by, and adapted to, stretching of the membrane. Adaptation of channel activity to mechanical stimuli was voltage-dependent. Because these mechanosensitive channels pass both cations and anions, they may play a role in turgor regulation in this walled organism
ISSN:0036-8075
1095-9203
DOI:10.1126/science.2460920