Mapping of a Gene for Parkinson's Disease to Chromosome 4q21-q23

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately 1 percent of the population over age 50. Recent studies have confirmed significant familial aggregation of PD and a large number of large multicase families have...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1996-11, Vol.274 (5290), p.1197-1199
Main Authors: Polymeropoulos, Mihael H., Higgins, Joseph J., Golbe, Lawrence I., Johnson, William G., Ide, Susan E., Di Iorio, Giuseppe, Sanges, Giuseppe, Stenroos, Edward S., Pho, Lana T., Schaffer, Alejandro A., Lazzarini, Alice M., Nussbaum, Robert L., Duvoisin, Roger C.
Format: Article
Language:English
Subjects:
Anatomy
Biological and medical sciences
Chromosome Mapping
Chromosomes
Chromosomes, Human, Pair 4
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Environmental Influences
Etiology
Family (Sociological Unit)
Female
Genes
Genetic aspects
Genetic Linkage
Genetic loci
Genetic Markers
Genetics
Heredity
Humans
Lod Score
Male
Medical research
Medical sciences
Nervous system diseases
Neurodegenerative diseases
Neurology
Parkinson disease
Parkinson Disease - genetics
Parkinson's disease
Pathology
Pedigree
Phenotype
Phenotypes
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Description
Summary:Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately 1 percent of the population over age 50. Recent studies have confirmed significant familial aggregation of PD and a large number of large multicase families have been documented. Genetic markers on chromosome 4q21-q23 were found to be linked to the PD phenotype in large kindred with autosomal dominant PD, with a Z$_{max}$=6.00 for marker D4S2380. This facilitate identification of the gene and research on the pathogenesis of PD.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.274.5290.1197