Properties of low density lipoproteins relevant to oxidative modifications change paradoxically during aging

Atherosclerosis is a common problem among the elderly. Because lipid peroxidation is considered a contributor to the development of atherosclerosis, we compared oxidative properties of lipoproteins in an otherwise healthy (SENIEUR-classified) aged population (65–74 years) with young controls (18–30...

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Bibliographic Details
Published in:Atherosclerosis 1996-09, Vol.126 (1), p.85-94
Main Authors: Stulnig, Thomas M., Jürgens, Günther, Chen, Qi, Moll, Denise, Schönitzer, Dieter, Jarosch, Elmar, Wick, Georg
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Aging
Aging - blood
Aldehydes - blood
Anti-oxidants
Antioxidants - analysis
Arteriosclerosis - metabolism
Ascorbic Acid - blood
Atherosclerosis
Biological and medical sciences
Development. Metamorphosis. Moult. Ageing
Fatty Acids - blood
Female
Fundamental and applied biological sciences. Psychology
Humans
Lipid Peroxidation
Lipoproteins, LDL - blood
Lipoproteins, LDL - chemistry
Low-density lipoproteins (LDL)
Male
Oxidation-Reduction
Polyunsaturated fatty acids
SENIEUR protocol
Thiobarbituric Acid Reactive Substances - analysis
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vitamins - blood
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Summary:Atherosclerosis is a common problem among the elderly. Because lipid peroxidation is considered a contributor to the development of atherosclerosis, we compared oxidative properties of lipoproteins in an otherwise healthy (SENIEUR-classified) aged population (65–74 years) with young controls (18–30 years). Relative amounts of oxidatively altered low density lipoprotein (LDL), estimated by means of an antibody against LDL modified by 4-hydroxynonenal, a product of lipid peroxidation, were increased marginally in serum from the elderly (9.8 vs. 7.4%, P = 0.07). In contrast, isolated LDL from the elderly revealed a decreased susceptibility to in vitro oxidation: the lag time was increased (2.34 vs. 2.10 h, P < 0.01), and the maximal rate of LDL oxidation decreased (0.88 vs. 1.01 O.D./h, P = 0.001). However, there were no age-related changes in lipid composition of native LDL and consumption of fatty acids during in vitro oxidation. The serum concentrations of ascorbic acid and most lipophilic anti-oxidants (the latter expressed per g serum lipids) were significantly decreased in the elderly except tocopherols which tended to be higher. In conclusion, our data reveal paradox age-related alterations of LDL as to its behaviour in oxidation in vivo vs. in vitro.
ISSN:0021-9150
1879-1484
DOI:10.1016/0021-9150(96)05896-0