CIGARETTE SMOKING AND SERUM SEX HORMONES IN MEN

The relation between cigarette smoking and serum sex hormone concentrations was examined in two samples of the Multiple Risk Factor Intervention Trial (MRFIT) population. One sample consisted of 121 men at the Pittsburgh, Pennsylvania MRFIT center who were followed longitudinally for four years. The...

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Bibliographic Details
Published in:American journal of epidemiology 1988-10, Vol.128 (4), p.796-805
Main Authors: DAI, WANJU S., GUTAI, JAMES P., KULLER, LEWIS H., CAULEY, JANE A.
Format: Article
Language:English
Subjects:
Adult
Aging - blood
Alcohol Drinking
androstenedione
Androstenedione - blood
Biological and medical sciences
Body Weight
Cholesterol - blood
estradiol
Estradiol - blood
estrone
Estrone - blood
Gonadal Steroid Hormones - blood
Humans
Longitudinal Studies
Male
Medical sciences
Middle Aged
sex hormones
smoking
Smoking - blood
testosterone
Testosterone - blood
Tobacco, tobacco smoking
Toxicology
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Summary:The relation between cigarette smoking and serum sex hormone concentrations was examined in two samples of the Multiple Risk Factor Intervention Trial (MRFIT) population. One sample consisted of 121 men at the Pittsburgh, Pennsylvania MRFIT center who were followed longitudinally for four years. The other sample was drawn from the entire MRFIT cohort and consisted of 163 MRFIT participants who subsequently developed coronary heart disease and 163 matched controls. The results indicated a positive correlation between cigarette smoking and serum total androstenedlone concentration. The association was independent of age, relative weight, alcohol drinking, blood pressure, and high density ilpoprotein (HDL) cholesterol. Serum total and free testosterone concentrations were positively correlated with cigarette smoking among the longitudinal sample and the controls, but not for the baseline sara from the coronary heart disease cases. This positive correlation was also independent of age, relative weight, alcohol drinking, blood pressure, and HDL cholesterol. There was no association between either serum estradiol or estrone concentrations and cigarette smoking in this population. These observations may have important implications for epidemiologic studies of diseases with significant smoking relations.
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a115033