A Gene Map of the Human Genome

The human genome is thought to harbor 50,000 to 100,000 genes, of which about half have been sampled to date in the form of expressed sequence tags. An international consortium was organized to develop and map gene-based sequence tagged site markers on a set of two radiation hybrid panels and a yeas...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1996-10, Vol.274 (5287), p.540-546
Main Authors: Schuler, G. D., Boguski, M. S., Stewart, E. A., Stein, L. D., Gyapay, G., Rice, K., White, R. E., Rodriguez-Tomé, P., Aggarwal, A., Bajorek, E., Bentolila, S., Birren, B. B., Butler, A., Chiannilkulchai, N., Chu, A., Clee, C., Cowles, S., Day, P. J. R., Dibling, T., Drouot, N., Dunham, I., Duprat, S., East, C., Edwards, C., J.-B. Fan, Fang, N., Fizames, C., Garrett, C., Green, L., Hadley, D., Harris, M., Brady, S., Hicks, A., Holloway, E., Hui, L., Hussain, S., C. Louis-Dit-Sully, Ma, J., MacGilvery, A., Mader, C., Maratukulam, A., Matise, T. C., McKusick, K. B., Mungall, A., Muselet, D., Nusbaum, H. C., Page, D. C., Peck, A., Perkins, S., Piercy, M., Qin, F., Quackenbush, J., Ranby, S., Reif, T., Rozen, S., Sanders, C., She, X., Silva, J., Slonim, D. K., Soderlund, C., W.-L. Sun, Tabar, P., Thangarajah, T., Vega-Czarny, N., Vollrath, D., Voyticky, S., Wilmer, T., Wu, X., Adams, M. D., Aufiray, C., Walter, N. A. R., Brandon, R., Dehejia, A., Goodfellow, P. N., Houlgatte, R., Hudson, J. R., Ide, S. E., Iorio, K. R., Lee, W. Y., Seki, N., Nagase, T., Ishikawa, K., Nomura, N., Phillips, C., Polymeropoulos, M. H., Sandusky, M., Schmitt, K., Berry, R., Swanson, K., Torres, R., Venter, J. C., Sikela, J. M., Weissenbach, J., Myers, R. M., Cox, D. R., James, M. R., Bentley, D., Deloukas, P., Lander, E. S., Hudson, T. J.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
Cell Line
Chromosome Mapping
Chromosomes
Chromosomes, Artificial, Yeast
Classical genetics, quantitative genetics, hybrids
Computer Communication Networks
Consortia
Databases, Factual
DNA, Complementary - genetics
Fundamental and applied biological sciences. Psychology
Gene Expression
Genes
Genetic loci
Genetic mapping
Genetic Markers
Genetics
Genetics of eukaryotes. Biological and molecular evolution
Genome, Human
Genomes
Human
Human genetics
Human genome
Human Genome Project
Humans
Maps (Geography)
Medical genetics
Multigene Family
RNA, Messenger - genetics
Sequence Homology, Nucleic Acid
Sequence Tagged Sites
Transcripts (Written Records)
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Description
Summary:The human genome is thought to harbor 50,000 to 100,000 genes, of which about half have been sampled to date in the form of expressed sequence tags. An international consortium was organized to develop and map gene-based sequence tagged site markers on a set of two radiation hybrid panels and a yeast artificial chromosome library. More than 16,000 human genes have been mapped relative to a framework map that contains about 1000 polymorphic genetic markers. The gene map unifies the existing genetic and physical maps with the nucleotide and protein sequence databases in a fashion that should speed the discovery of genes underlying inherited human disease. The integrated resource is available through a site on the World Wide Web at http://www.ncbi.nlm.nih.gov/SCIENCE96/.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.274.5287.540