Left Ventricular Mass and Exercise Responses Predict Future Blood Pressure The Muscatine Study

Increased blood pressure and left ventricular mass are associated with increased morbidity and mortality in adults with coronary heart disease. To define the predictors of subsequent childhood blood pressure and left ventricular mass, serial echocardiograms and blood pressure responses during exerci...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1988-08, Vol.12 (2), p.206-213
Main Authors: MAHONEY, LARRY T, SCHIEKEN, RICHARD M, CLARKE, WILLIAM R, LAUER, RONALD M
Format: Article
Language:English
Subjects:
Adolescent
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Cardiology. Vascular system
Child
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Coronary Disease - etiology
Coronary Disease - prevention & control
Echocardiography
Female
Heart - anatomy & histology
Heart - physiology
Humans
Iowa
Longitudinal Studies
Male
Mass Screening
Medical sciences
Physical Exertion
Risk Factors
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Summary:Increased blood pressure and left ventricular mass are associated with increased morbidity and mortality in adults with coronary heart disease. To define the predictors of subsequent childhood blood pressure and left ventricular mass, serial echocardiograms and blood pressure responses during exercise were studied in 274 children aged 6 to IS years, whose systolic blood pressures were in the high, middle, or low range. Persistence of rank order for left ventricular mass and blood pressure, at rest and during exercise, was maintained over a mean follow-up period of 3.4 years, with correlations ranging from 0.33 to 0.44. Subsequent systolic blood pressure was best predicted from initial resting and maximal exercise systolic blood pressures and left ventricular mass. Subsequent left ventricular mass was best predicted from initial left ventricular mass and maximal exercise diastolic blood pressure, but resting systolic blood pressure did not add to this latter prediction. Since left ventricular mass relates best to exercise blood pressure and not to resting Mood pressure, left ventricular mass may provide an integrated view of the effects of blood pressure both at rest and during stress. We speculate that increased left ventricular mass in childhood may be an important predictor of subsequent hypertension and its consequences.
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.12.2.206