Abnormal postprandial apolipoprotein B-48 and triglyceride responses in normolipidemic women with greater than 70% stenotic coronary artery disease: a case-control study

Because remnants of triglyceride-rich lipoproteins (TRLP) are potentially atherogenic, the postprandial lipoprotein metabolism was studied in 12 normocholesterolemic, normotriglyceridemic women, aged 60 ± 2 years, with angiographically proven coronary artery disease (CAD +; cholesterol 5.7 ± 0.1 (S....

Full description

Saved in:
Bibliographic Details
Published in:Atherosclerosis 1996-08, Vol.124 (2), p.221-235
Main Authors: Meyer, Ellen, Westerveld, H.Tineke, de Ruyter-Meijstek, Florianne C., van Greevenbroek, Marleen M.J., Rienks, Rienk, van Rijn, Herman J.M., Erkelens, D.Willem, de Bruin, Tjerk W.A.
Format: Article
Language:English
Subjects:
Analysis of Variance
Anticoagulants - therapeutic use
Apolipoprotein B-48
Apolipoproteins B - blood
Biological and medical sciences
Cardiology. Vascular system
Case-Control Studies
Cholesterol - blood
Coronary Angiography
Coronary artery disease
Coronary Disease - blood
Coronary Disease - diagnostic imaging
Coronary Disease - drug therapy
Coronary heart disease
Electrophoresis, Polyacrylamide Gel
Female
Heart
Heparin - therapeutic use
Humans
Intermediate density lipoproteins
Lipoprotein Lipase - metabolism
Lipoproteins - blood
Lipoproteins, IDL
Liver - drug effects
Liver - metabolism
Medical sciences
Middle Aged
Postprandial Period - physiology
Radioimmunoassay
Retinyl palmitate
Retrospective Studies
Risk Factors
Triglycerides - blood
Ultracentrifugation
Very low density lipoproteins
Vitamin A - analogs & derivatives
Vitamin A - blood
Women
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Because remnants of triglyceride-rich lipoproteins (TRLP) are potentially atherogenic, the postprandial lipoprotein metabolism was studied in 12 normocholesterolemic, normotriglyceridemic women, aged 60 ± 2 years, with angiographically proven coronary artery disease (CAD +; cholesterol 5.7 ± 0.1 (S.E.) mmol/l, triglyceride 1.35 ± 0.10 mmol/l) and in 12 individually matched controls, aged 59 ± 2 years, without angiographical abnormalities (CAD −; cholesterol 5.1 ± 0.2 mmol/l and triglyceride 1.16 ± 0.13 mmol/l). Following an oral retinyl palmitate-fat load, the CAD + women showed a significantly higher triglyceride response in the chylomicron, or Sf > 1000, fraction ( P < 0.05 vs. controls). Total plasma apolipoprotein (apo) B and retinyl palmitate concentrations were similar in both groups. Fasting apo B-48 levels in the d < 1.006 g/ml fraction were significantly higher in CAD + cases (0.25 ± 0.03 integrated optical density (iod) units) than CAD − controls (0.15 ± 0.03; P < 0.05). Furthermore, after the fat load, a greater absolute and incremental apo B-48 response in the intermediate density lipoprotein (IDL) fraction ( d= 1.006 – 1.019 g/ml) was observed in CAD + cases (incremental area under the curve (Delta-AUC)8: 0.40 ± 0.12 h.iod) than CAD − controls (0.01 ± 0.06 h.iod; P = 0.01). Post-heparin hepatic lipase (HL) activities were higher in the CAD + group; 422 ± 22 mU/l vs 288 ± 20 mU/ml in the CAD − group ( P < 0.001) while lipoprotein lipase (LPL) activities were identical. The results provide evidence that the metabolism of intestinal TRLP is significantly different in normolipidemic women with angiographically proven CAD compared with individually matched controls without coronary disease. Fasting apo B-48 levels in d < 1.006 g/ml fractions represent a potentially useful marker in women at risk for CAD.
ISSN:0021-9150
1879-1484
DOI:10.1016/0021-9150(96)05832-7