Familial predisposition for degenerative disc disease : A case control study

This case-control study was undertaken to determine if relatives of patients who had been admitted for surgery for degenerative disc disease-related problems were at increased risk for lower back pain or sciatica. To determine if familial factors play a role in placing a person at risk for developme...

Full description

Saved in:
Bibliographic Details
Published in:Spine (Philadelphia, Pa. 1976) Pa. 1976), 1996-07, Vol.21 (13), p.1527-1529
Main Authors: SIMMONS, E. D, GUNTUPALLI, M, KOWALSKI, J. M, BRAUN, F, SEIDEL, T
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Case-Control Studies
Diseases of the osteoarticular system
Family Health
Female
Humans
Incidence
Intervertebral Disc - pathology
Intervertebral Disc - surgery
Intervertebral Disc Displacement - diagnosis
Intervertebral Disc Displacement - epidemiology
Intervertebral Disc Displacement - genetics
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Osteoarthritis
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This case-control study was undertaken to determine if relatives of patients who had been admitted for surgery for degenerative disc disease-related problems were at increased risk for lower back pain or sciatica. To determine if familial factors play a role in placing a person at risk for development of degenerative disc disease of the lumbar spine. It is known that smoking and various occupational factors can place a person at risk for degenerative disc disease problems. It is not known if a familial predisposition may also exist. The family members and relatives of 65 patients who had undergone surgery for lumbar degenerative disc disease were interviewed with a standardized questionnaire and compared with a control group of 67 patients who had been admitted to hospital for non-spine-related orthopedic procedures. The same interview and standardized questionnaire was used for both groups by a single observer. In the study group of 65 patients who had undergone surgery for degenerative disc disease, 44.6% were noted to have a positive family history, whereas 25.4% of the patients in the control group had a positive family history. Eighteen and one-half percent of relatives in the study group had a history of having spinal surgery, compared with only 4.5% of the control group. The results indicate that a familial predisposition to degenerative disc disease can exist along with other risk factors.
ISSN:0362-2436
1528-1159
DOI:10.1097/00007632-199607010-00007