Specific cross-immunity between Hymenolepis nana and H. diminuta: immunization with heterologous and homologous light infections

The consequences of previous and concurrent infection with two related species of cestodes, Hymenolepis nana and H. diminuta, were studied in CD1 mice. A H. diminuta infection strongly affected the establishment and the survival of a secondary H. nana egg or cyst infection administered 30 days later...

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Bibliographic Details
Published in:Journal of helminthology 1988-06, Vol.62 (2), p.115-123
Main Authors: Gabriele, F., Wakelin, D., Palmas, C.
Format: Article
Language:English
Subjects:
Animals
concurrent infection
cross immunity
Cross Reactions
cysts
Female
Hymenolepiasis - immunology
Hymenolepis diminuta
Hymenolepis nana
immune response
immune responses
immunity
Immunization
immunogenetics
immunogenicity
Immunologic Memory
infection
lumenal phase
Mice
Mice, Inbred Strains
Nematoda
ova
Ovum - immunology
Praziquantel
Recurrence
Research Papers
tissue phase
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Summary:The consequences of previous and concurrent infection with two related species of cestodes, Hymenolepis nana and H. diminuta, were studied in CD1 mice. A H. diminuta infection strongly affected the establishment and the survival of a secondary H. nana egg or cyst infection administered 30 days later. An infection of 20 H. nana eggs strongly protected against a 5-cyst H. diminuta challenge, whereas an infection of 10 H. nana cysts was ineffective; 20 H. nana eggs also protected against a challenge with 5 cysts of H. diminuta administered 5 days later. No effects were observed in either parasite during a concurrent infection established by administration of cysts. An H. nana egg-infection was unable to affect the establishment of a secondary H. nana cyst-infection given 1 month later; however a significant decrease in growth was found. Similar results were found when a primary H. nana egg-infection was followed 5 days later by the homologous cyst-infection. But an infection with 5 H. nana cysts was unable to protect against a homologous challenge of 5 cysts or 20 eggs. The reciprocal cross immunity between the heterologous parasites and the failure of protection of homologous challenges are discussed in relation to light infections.
ISSN:0022-149X
1475-2697
DOI:10.1017/S0022149X00011342