The d4 Gene Family in the Human Genome

The d4 domain, a novel zinc finger-like structural motif, was first revealed in the rat neuro-d4 protein. Here we demonstrate that the d4 domain is conserved in evolution and that three related genes form a d4 family in the human genome. The human neuro-d4 is very similar to rat neuro-d4 at both the...

Full description

Saved in:
Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 1996-08, Vol.36 (1), p.174-177
Main Authors: Chestkov, Alexander V., Baka, Ivan D., Kost, Maria V., Georgiev, Georgy P., Buchman, Vladimir L.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Caenorhabditis elegans
Chromosome Mapping
Chromosomes, Human, Pair 19 - genetics
Conserved Sequence
Exons - genetics
Genome, Human
Humans
Molecular Sequence Data
Multigene Family - genetics
Nerve Tissue Proteins - genetics
Rats
RNA Splicing
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
Transcription Factors
Zinc Fingers - genetics
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The d4 domain, a novel zinc finger-like structural motif, was first revealed in the rat neuro-d4 protein. Here we demonstrate that the d4 domain is conserved in evolution and that three related genes form a d4 family in the human genome. The human neuro-d4 is very similar to rat neuro-d4 at both the amino acid and the nucleotide levels. Moreover, the same splice variants have been detected among rat and human neuro-d4 transcripts. This gene has been localized on chromosome 19, and two other genes, members of the d4 family isolated by screening of the human genomic library at low stringency, have been mapped to chromosomes 11 and 14. The gene on chromosome 11 is the homolog of the ubiquitously expressed mouse gene ubi-d4/requiem, which is required for cell death after deprivation of trophic factors. A gene with a conserved d4 domain has been found in the genome of the nematodeCaenorhabditis elegans.The conservation of d4 proteins from nematodes to vertebrates suggests that they have a general importance, but a diversity of d4 proteins expressed in vertebrate nervous systems suggests that some family members have special functions.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1996.0440