Prolonged Enteroviral Infection in a Patient Who Developed Pericarditis and Heart Failure After Bone Marrow Transplantation

We describe a patient who developed heart failure and pericarditis after bone marrow transplantation for a hematologic malignancy. The patient died of heart failure complicated by pneumonia. Despite extensive surveillance~ an infectious cause for the heart failure was not found while he was alive. I...

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Bibliographic Details
Published in:Clinical infectious diseases 1996-06, Vol.22 (6), p.1004-1008
Main Authors: Galama, Joep M. D., de Leeuw, Nicole, Wittebol, Shulamiet, Peters, Herman, Melchers, Willem J. G.
Format: Article
Language:English
Subjects:
Adult
Antibodies
Base Sequence
Biological and medical sciences
Bone Marrow Transplantation - adverse effects
Cardiac Output, Low - drug therapy
Cardiac Output, Low - etiology
Clinical Articles
Cytomegalovirus
Enterovirus
Enterovirus - genetics
Enterovirus Infections - complications
Enterovirus Infections - diagnosis
Enterovirus Infections - drug therapy
Fatal Outcome
Heart
Hodgkin Disease - complications
Hodgkin Disease - drug therapy
Hodgkin Disease - radiotherapy
Human viral diseases
Humans
Infections
Infectious diseases
Lungs
Male
Medical sciences
Miscellaneous
Molecular Sequence Data
Pericarditis
Pericarditis - drug therapy
Pericarditis - etiology
Pleural Effusion - virology
Polymerase Chain Reaction
RNA
RNA, Viral - analysis
Viral diseases
Viruses
Citations: Items that cite this one
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Description
Summary:We describe a patient who developed heart failure and pericarditis after bone marrow transplantation for a hematologic malignancy. The patient died of heart failure complicated by pneumonia. Despite extensive surveillance~ an infectious cause for the heart failure was not found while he was alive. In addition~ cultures of specimens obtained at autopsy did not reveal a cause for the heart failure. Enterovirus was detected by the polymerase chain reaction (PCR) in two samples of pleural fluid that were obtained 21 days apart while he was alive. After the patient died~ enteroviral RNA was also detected in his lungs~ liver~ and spleen, indicating a generalized infection. Analysis of the PCR products revealed sequences sharing close homology with the coxsackie B-like group of enteroviruses. In addition to reporting this case~ we review the literature regarding enteroviral infections after transplantation.
ISSN:1058-4838
1537-6591
DOI:10.1093/clinids/22.6.1004