Effects of in vivo cocaine administration on human platelet aggregation

To evaluate whether cocaine administration to human volunteers in vivo increases platelet aggregation, 12 healthy male volunteers were studied twice in a prospective, double-blinded fashion. There was a decrease in aggregation following cocaine exposure compared to placebo, which was most prominent...

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Bibliographic Details
Published in:	The American journal of cardiology 1996-07, Vol.78 (2), p.237-239
Main Authors:	Heesch, C M, Negus, B H, Steiner, M, Snyder RW, I I, McIntire, D D, Grayburn, P A, Ashcraft, J, Hernández, J A, Eichhorn, E J
Format:	Article
Language:	eng
Subjects:	Adult Analysis of Variance Cardiovascular disease Cocaine Cocaine - blood Cocaine - pharmacology Dose-Response Relationship, Drug Double-Blind Method Drug therapy Humans Male Medical research Middle Aged Multivariate Analysis Nephelometry and Turbidimetry Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology Prospective Studies
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Summary:	To evaluate whether cocaine administration to human volunteers in vivo increases platelet aggregation, 12 healthy male volunteers were studied twice in a prospective, double-blinded fashion. There was a decrease in aggregation following cocaine exposure compared to placebo, which was most prominent at high doses of adenosine diphosphate.
ISSN:	0002-9149 1879-1913